Ahmed Zuwaiel Shatti Alanazi

My research primarily focuses on cardiovascular pathophysiology, with an emphasis on hypertension. Our work investigates the molecular and physiological functions of Angiotensin III (Ang III) and other peptides within the renin-angiotensin-aldosterone system (RAAS) in vascular smooth muscle cells (VSMCs).

Our long-term research objective is to elucidate how Ang III modulates intracellular signaling pathways, such as mitogen-activated protein kinases (MAPKs) and the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathways, which may be dysregulated in hypertensive states. Utilizing primary VSMCs isolated from both normotensive (Wistar) and spontaneously hypertensive rats (SHRs), our studies aim to delineate the role of Ang III in promoting cellular proliferation and inflammation, and to compare its effects with those of Angiotensin II (Ang II). This comparative approach has revealed key mechanistic differences between normotensive and hypertensive models, offering valuable insights into the pathogenesis of hypertension and potential therapeutic targets.

Our findings underscore the pivotal role of Ang III in regulating blood pressure through the modulation of critical signaling pathways and gene expression in VSMCs. By deepening our understanding of the distinct molecular mechanisms driven by Ang III, our research lays the groundwork for novel therapeutic strategies aimed at managing hypertension and other disorders associated with RAAS dysregulation.