Skip to main content
User Image

Saeedah Musaed Almutairi

Assistant Professor

عضو هيئه تدريس

كلية العلوم
مبنى رقم 5، الدور 3، مكتب 151
publication
Journal Article
2019

Natural killer cell-derived IL-10 regulates T cell response to prevent liver damage during sustained murine cytomegalovirus infection

Lee, Alaa Kassim Ali, Amandeep Kaur Komal, Saeedah Musaed Almutairi, and Seung-Hwan . 2019

Natural Killer (NK) cells are lymphocytes of the innate immune response that play a vital role in controlling infections and cancer. Their pro-inflammatory role has been well-established; however, less is known about the regulatory functions of NK cells, in particular, their production of the anti-inflammatory cytokine IL-10. In this study, we investigated the immunoregulatory function of NK cells during MCMV infection and demonstrated that NK cells are major producers of IL-10 during the early stage of infection. To investigate the effect of NK cell-derived IL-10, we have generated NK cell-specific IL-10-deficient mice (NKp46-Cre-Il10 fl/fl ) displaying no signs of age-related spontaneous inflammation, with NK cells that show no detectable IL-10 production upon in vitro stimulation. In NKp46-Cre-Il10 fl/fl mice, the levels of IL-10 and IFNγ, viral burdens and T cell activation were similar between NKp46-Cre-Il10 fl/fl mice and their control littermates, suggesting that NK cell-derived IL-10 is dispensable during acute MCMV infection in immunocompetent hosts. In perforin-deficient mice that show a more sustained infection, NK cells produce more sustained levels of IL-10. By crossing NKp46-Cre-Il10 fl/flmice with perforin-deficient mice, we demonstrated that NK cell-derived IL-10 regulates T cell activation, prevents liver damage, and allows for better disease outcome. Taken together, NK cell-derived IL-10 can be critical in regulating the immune response during early phases of infection and therefore protecting the host from excessive immunopathology.

Publication Work Type
دكتوراه
more of publication
publications

Upon inflammation, natural killer (NK) cells undergo metabolic changes to support their high energy demand for effector function and proliferation. The metabolic changes are usually accompanied by…

by Saeedah Musaed Almutairi*, Alaa Kassim Ali*, William He, Doo-Seok Yang, Peyman Ghorbani, Lisheng Wang, Morgan D Fullerton and Seung-Hwan Lee
2019
publications

Natural Killer (NK) cells are lymphocytes of the innate immune response that play a vital role in controlling infections and cancer. Their pro-inflammatory role has been well-established; however…

by Alaa Kassim Ali, Amandeep Kaur Komal, Saeedah Musaed Almutairi, and Seung-Hwan Lee
2019