The Effect of Local Renin Angiotensin System in the Common Types of Cancer.
Moudhi Almutlaq1,2*, Abir Abdullah Alamro2, Hassan S. Alamri1,3, Amani Ahmed Alghamdi2 and Tlili Barhoumi1,3*
1King Abdullah International Medical Research Centre, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia
2Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia
3Medical Research Core Facility and Platforms, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
Abstract
The Renin Angiotensin System (RAS) is a hormonal system that is responsible for blood pressure hemostasis and electrolyte balance. It is implicated in cancer hallmarks because it is expressed locally in almost all of the body's tissues. In this review, current knowledge on the effect of local RAS in the common types of cancer such as breast, lung, liver, prostate and skin cancer is summarised. The mechanisms by which RAS components could increase or decrease cancer activity are also discussed. In addition to the former, this review explores how the administration of AT1R blockers and ACE inhibitors drugs intervene with cancer therapy and contribute to the outcomes of cancer.
Keywords: ACE inhibitors; AT1R blockers; Ang 1-7; Ang II; Urotensin II; cancer; renin angiotensin system.
Copyright © 2021 Almutlaq, Alamro, Alamri, Alghamdi and Barhoumi
