Synthesis, characterization, density functional theory, thermal, antimicrobial efficacy, and DNA binding/cleavage studies of Cu( II), Cr(III), Fe(III), Ni(II ), Co(II), Zn(II), and Pt(IV) complexes with a derivative of 2‐hydroxyphenoxymethylfuran‐5‐carbal

Journal Article

2020

Published in: https://doi.org/10.1002/jccs.202000042

M., Al‐Mohaimeed, Amal . 2020

In this study, Seven new complexes incorporating (E)-2-(((5-([2-hydroxyphenoxy]methyl)furan-2-yl)methylene)amino)phenol derived from 2-hydroxyphenoxymethylfuran-5-carbaldehyde and 2-aminophenol have been synthesized using Cu(II), Cr(III), Fe(III), Ni(II), Co(II), Zn(II), and Pt(IV) metal salts. Thermal measurements, molar conductance, magnetic moment, elemental analyses, spectral (IR, UV–Vis, 1H nuclear magnetic resonance (NMR), ESR, Mass), were used to characterize insulated solid complexes. The thermogravimetry (TG) and differential thermoanalysis (DTA) of the complexes were carried out in the range of 30–900°C. Magnetic susceptibility and electronic spectral data, as well as quantum chemical calculations, reveal the square planar geometry for Ni (II) complex, square planar/octahedral geometry for Cu (II) complex, while Co(II), Zn(II), Cr(III), Fe(III), and Pt (IV) complexes are octahedral geometry. Density functional theory (DFT) studies revealed that geometries of metal complexes and Schiff base were entirely optimized in relation to use energy by 6–31 + g (d,p) basis set. The complexes show a well-defined crystal system indicated by a powder-X-ray diffraction pattern. The scanning electron microscope showed complexes were nanocrystalline in nature, in addition to the interaction of the complexes with calf thymus CT-DNA, which was investigated via the UV–visible absorption method. Therefore, the DNA cleavage activity by the H2L ligand and its metal complexes was performed. Finally, the synthesized complexes were tested for their in-vitro antimicrobial efficacy.

• Magazine \ Newspaper: Journal of the Chinese Chemical Society