BITC and S-Carvone Restrain High-fat Diet-induced Obesity and Ameliorate Hepatic Steatosis and Insulin Resistance
, Alsanea S . 2017
Purpose: To investigate the preventative activity of benzylisothiocyante and S-carvone against high-fat diet-induced obesity and metabolic complications.
Methods: Ten-week-old C57BL/6 male mice were fed a high-fat diet and injected intraperitoneally twice per week with benzylisothiocyante, S-carvone, or vehicle for 8 weeks. The body weight, food intake, and body composition were monitored, and glucose tolerance and insulin tolerance tests were performed at the end of the experiment. Serum and tissue samples were studied using serum biochemistry, histological, and gene expression analysis to define the effects of benzylisothiocyante and S-carvone treatments on lipid and glucose metabolism and inflammatory responses.
Results: Benzylisothiocyante and S-carvone blocked high-fat diet-induced weight gain, fat accumulation in the liver, and insulin resistance. The beneficial effects were found to be associated with an improvement of expression of macrophage marker genes in white adipose tissue including F4/80, Cd11b, Cd11c, Cd206, and Tnf-a, and reduced expression of genes (Pparg2, Scd1, Cd36) responsible for lipid synthesis and transport in the liver.
Conclusion: Benzylisothiocyante and S-carvone block high-fat diet- induced obesity and metabolism disorders and can be considered for management of obesity epidemics that affects about 36% adults and 17% children in the USA.
في خمسينيات وستينيات القرن الميلادي الماضي بدأ الاهتمام العالمي بالتيقظ الدوائي؛ لما له من أهمية على المأمونية الدوائية والآثار الجانبية، وقد توسع علم التيقظ الدوائي وأصبح له قوانين من قبل السلطات…
Purpose: To investigate the preventative activity of benzylisothiocyante and S-carvone against high-fat diet-induced obesity and metabolic complications.
Reactive oxygen species generated as a byproduct in metabolism play a central role in the development of obesity and obesity-related metabolic complications.