Effect of mechanical debridement with and without adjunct antimicrobial photodynamic therapy for the treatment of peri-implant disease in obese patients: A systematic review and meta-analysis of randomized controlled trials
Objective
The aim of the present systematic review and meta-analysis was to assess the effect of mechanical debridement (MD) with and without adjunct antimicrobial photodynamic therapy (aPDT) for the treatment of peri‑implant diseases in obese patients.
Methods
The focused question is “Is MD with adjuvant aPDT more effective than MD alone for treating peri‑implant diseases in obese patients?” Indexed databases were searched without time and language barriers up to and including February 2025. Various keywords were used in different combinations using Boolean operators. A forest plot was generated to visually present the results of the meta-analysis. The risk of bias (RoB) within studies was assessed and GRADE analysis was performed.
Results
Three randomized controlled trials (RCTs) were included. The number of participants ranged between 49 and 80 individuals. Patients in the test and control groups underwent MD with and without adjunct aPDT, respectively. In two studies, periimplantitis was treated with MD with and without adjunct aPDT, and in one, MD with and without MD was performed to treat peri‑implant mucositis. Follow-up ranged from 3 to 6 months. All RCTs showed that MD+aPDT is more effective in treating peri‑implant diseases than MD alone. The RoB was high and unclear in one and two RCTs, respectively. The meta-analysis showed that control intervention provided a more favorable outcome than experimental intervention. The certainty of evidence was low, and the strength of recommendation was weak in all RCTs.
Conclusion
Role of aPDT as an adjunct to MD for treating peri‑implant diseases in obese populations remains unclear.
Objective
The aim of the present systematic review and meta-analysis was to assess the effect of mechanical debridement (MD) with and without adjunct antimicrobial…
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