تجاوز إلى المحتوى الرئيسي
User Image

ريم منصور عبدالله الجويعي

Associate Professor

عضو هيئة تدريس

كلية العلوم
كلية العلوم مبنى 5 ، الدور 3 ، مكتب 328
المنشورات
مقال فى مجلة
2023

AI-driven Discovery of Celecoxib and Dexamethasone for Exploring their Mode of Action as Human Interleukin (IL-6) Inhibitors to Treat COVID-19-induced Cytokine Storm in Humans

n the case of COVID-19 patients, it has been observed that the immune system of the infected person exhibits an extreme inflammatory response known as cytokine release syndrome (CRS) where the inflammatory cytokines are swiftly produced in quite large amounts in response to infective stimuli. Numerous case studies of COVID-19 patients with severe symptoms have documented the presence of higher plasma concentrations of human interleukin-6 (IL-6), which suggests that IL-6 is a crucial factor in the pathophysiology of the disease. In order to prevent CRS in COVID-19 patients, the drugs that can exhibit binding interactions with IL-6 and block the signaling pathways to decrease the IL-6 activity may be repurposed.

مزيد من المنشورات
publications

n the case of COVID-19 patients, it has been observed that the immune system of the infected person exhibits an extreme inflammatory response known as cytokine release syndrome (CRS) where the…

2023
publications

The aim of this work was to assess the effects of typical and optimal use of sunscreens…

2023