The plant flavonoid, fisetin alleviates cigarette smoke‐induced oxidative stress, and inflammation in Wistar rat lungs
Alrokayan, Tajamul Hussain Omar S. Al‐Attas Salman Alamery Mukhtar Ahmed Hamza A. M. Odeibat Salman . 2019
n the present study, we tested the antioxidant and anti‐inflammatory potential of the plant flavonoid, fisetin against cigarette smoke‐induced oxidative stress, and inflammation in rat lungs. Male Wistar rats were chronically exposed to cigarette smoke (CS) with or without administration of fisetin. Fisetin administration to CS‐exposed rats resulted in a significant reduction in neutrophils and macrophages in bronchoalveolar lavage fluid as well as malondialdehyde, 3‐nitrotyrosine, 8‐isoprostane, tumor necrosis factor‐alpha, interleukin‐1beta, granulocyte macrophage‐colony stimulating factor, interleukin‐4, and interleukin‐10 levels in lung tissues compared to those in CS‐exposed rats not treated with fisetin. Fisetin also significantly augmented lung hemoxinase‐1, glutathione peroxidase‐2, reduced glutathione, superoxide dismutase, nitric oxide, and nuclear factor erythroid 2‐related factor (Nrf2) levels in CS‐exposed rats. In addition, a marked reversal in CS‐induced histopathological changes was noted in fisetin‐treated rats. Collectively, these data demonstrate the potential of fisetin to blunt CS‐induced oxidative stress and inflammation in the lung and to prevent tissue damage via the Nrf2‐mediated upregulation of antioxidant gene expression.
Abstract
Objectives: To assess circulating fetuin A and fetuin B levels in participants with and without Gestational Diabetes Mellitus (GDM) and to find out their correlations with other…