Anti-Inflammatory and Antioxidative Potential of Aloe vera on the Cartap and Malathion Mediated Toxicity in Wistar Rats

مقال فى مجلة
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Abstract: Aloe vera has been the most useful medicinal herb in the world since ancient times due
to its vast biological effects. The presence of high content of bioactive compounds make Aloe
vera a promising complementary and alternative agent in disease prevention. The effectiveness
of A. vera-based medicines against pesticide toxicity has never been evaluated. It was therefore
envisaged to develop an A. vera-based strategy to protect the non-target animals from adverse effects
of the pesticides. This article illustrates the ameliorating effect of aqueous extract (AE) of A. vera leaves
against the cartap and malathion toxicity. To evaluate the protective impact of A. vera against cartap
(Ctp), malathion (Mtn) and a mixture of both pesticides, the animals were divided in eight groups,
each containing six rats: Group 1- C (control), Group 2- AE + C, Group 3- Ctp, Group 4- Mtn, Group 5-
Ctp + Mtn, Group 6- AE + Ctp, Group 7- AE + Mtn, Group 8- AE + Ctp + Mtn. Wistar rats exposed to
Ctp, Mtn and Ctp + Mtn, displayed significant change in body weight. It was observed that the WBC
level increased significantly in Mtn and Ctp + Mtn challenged groups. The contents of TNF-α and
IL-6 in serum increased expressively in the Ctp, Mtn and Ctp + Mtn challenged groups. Rats treated
with Ctp, Mtn and Ctp + Mtn displayed significant alterations in the levels of antioxidative indices
(MDA, GSH, GST, GPx, SOD and CAT). Significant alterations were recorded in the activities of AST,
ALT, ACP and ALP in Ctp, Mtn and Ctp + Mtn challenged groups. The histopathological results of
liver supported the biochemical data. The pre-treatment of rats with the aqueous extract of A. vera
leaves significantly protected them from the toxicity of pesticides. These results suggested that A. vera
extract may be used as a promising natural agent for the management of pesticide induced toxicity.