Novel synthesis of CNTs/Cu nanodots-arabic gum nano-hybrid composites induce cytotoxicity and apoptosis in human breast and lung cancer cell lines
This research introduces a new hybrid material for potential cancer treatment. It combines carbon nanotubes decorated with copper nanodots and Arabic gum through an electroless reduction deposition technique. The resulting nanocomposite was thoroughly characterized confirming the successful decoration of carbon nanotubes with copper nanodots ranging in size from 1.55 to 7.77 nm. The hybrid material exhibits a high zeta-potential of − 20.3 mV, indicating excellent stability due to surface charge. The nanocomposite demonstrated cytotoxicity against MCF-7 breast cancer cells and A549 lung cancer cells in a dose-dependent manner. Notably, MCF-7 cells showed higher sensitivity to the hybrid material with (IC50) of 30.8 μg/ml compared to A549 cells with an IC50 of 48.23 μg/ml. Furthermore, the hybrid induced apoptosis in treated cells, as confirmed by apoptotic-related markers. This novel hybrid material holds promising potential for cancer therapy due to its high stability, targeted cytotoxicity, and induce apoptosis in cancer cells.
This research introduces a new hybrid material for potential cancer treatment. It combines carbon nanotubes decorated with copper nanodots and Arabic gum through an electroless reduction…
Background: Nanotechnology has emerged as a novel research area to address the several problems associated with existing cancer treatments.
Liver cancer is often highly fatal due to poor prognosis. The treatment approaches are continuously evolving with the advancements in technology.