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نوال أحمد عبدالرحمن العرفج

Professor

أستاذ دكتور في الكيمياء التحليلية/قسم الكيمياء/كلية العلوم

كلية العلوم
المدينة الجامعية للطالبات - كلية العلوم (مبنى 5) - الدور 3 - مكتب 336
المنشورات
مقال فى مجلة
2024

A Dual-Mode Spectrophotometric and Fluorescent Probe Based on Lignin-Derived Carbon Dots for the Detection of Atorvastatin Calcium in a Bulk Powder and a Commercial Product

Recently, dual-mode techniques have garnered considerable attention and have been shown to be effective approaches for biomedical analysis and environmental monitoring. A novel and simple dual-mode spectrophotometric and fluorometric probe based on lignin-derived carbon dots (LCDs) was developed to detect atorvastatin calcium (ATS) in a bulk powder and its commercial product. The synthesized LCDs exhibit exceptional fluorescence characteristics and are highly soluble in water while maintaining reasonable stability. The average particle size of the LCDs was 3.42±1.03 nm. The characterization of the produced LCDs indicated a structure resembling graphene oxide with the presence of several functional groups. The developed LCDs show a good fluorescence quantum yield of 32.2%. The fluorescence of the LCDs is quenched by ATS at an emission wavelength of 315 nm after excitation at 275 nm through dynamic and static quenching mechanisms. The optimal reaction conditions for the dual-mode reaction were a pH of 9 and 0.05 mL of the LCDs, which were measured after 3 min at 30 °C by spectrophotometry, followed by 7 min at 20 °C by fluorometric methods. According to the spectrophotometric results, the response of ATS was linear in the range of 4.0–100.0 µg/mL, while according to the fluorometric results, the dynamic range was 3.0–50.0 µg/mL. The limits of detection (LODs) and the limits of quantification (LOQs) were 0.97 µg/mL and 2.95 µg/mL for the fluorometric method, respectively. The nanoprobe effectively analyzed ATS in medication samples and yielded good results

نوع عمل المنشور
دكتوراه
اسم الناشر
Journal of Fluorescence
مزيد من المنشورات
publications

Due to massive industrial development, organic and inorganic wastes are very common in most industrial efuents from the pharmaceutical industry. Even in low concentrations, they are very dangerous…

بواسطة Nawal Alarfaj, Nawal Al Musayeib, Musarat Amina, Maha El‑Tohamy
2024
تم النشر فى:
Environmental Science and Pollution Research
publications

Recently, carbon dots (CDs) have been extensively investigated as potential tools for numerous applications. Modified lignin-based CDs have been synthesized and used in the field of drug detection…

بواسطة Fatemah Aldakhil, Nawal A. Alarfaj, Salma A. Al-Tamimi, Maha F. El-Tohamy
2024
تم النشر فى:
RSC Advances
publications

Recently, dual-mode techniques have garnered considerable attention and have been shown to be effective approaches for biomedical analysis and environmental monitoring.

بواسطة Fatemah Aldakhil, Nawal A. Alarfaj, Salma A. Al-Tamimi, Maha F. El-Tohamy
2024
تم النشر فى:
Journal of Fluorescence