Characterization and biological investigation of silver nanoparticles biosynthesized from Galaxaura rugosa against multidrug-resistant bacteria
ABSTRACTBacterial drug resistance poses a global challenge to established antibacterial preventionand treatment schemes. Recent approaches focus on raising algal extracts’ efficacy by fusingthem to other antibacterial agents employing nanotechnology. Here, we successfully biosyn-thesized AgNPs using Galaxaura rugosa crude methanol extract (AgNPCR) and raw powderaqueous (AgNPAQ) solution. The resultant AgNPs were characterized using UV-visible spec-troscopy, Fourier-transform infrared spectroscopy, dynamic light scattering, and transmissionelectron microscopy. The AgNPs were spherical and ranged between 60 to 114.4 nm. Thepresence of the hydroxyl group and alkenes propped AgNPs biosynthesis. We investigatedAgNPs antibacterial and antibiofilm activity against eighteen medically important bacteria,including multidrug-resistant bacteria. The sensitive and resistant Acinetobacter baumannii andStaphylococcus aureus were the most affected strains. The biofilm of MDR strains was mostlydisturbed, indicating the reduced bacterial fitness in resistant strains. These results may aidantibacterial agents’ development by investing in natural resources available abundantly in ourenvironment.
Abstract
ABSTRACTBacterial drug resistance poses a global challenge to established antibacterial preventionand treatment schemes. Recent approaches focus on raising algal extracts’ efficacy by fusingthem…