Aminoglycosides are bactericidal antibiotics used in the systemic treatment of serious Gram-negative infections. Multiple-daily dosing (MDD) has been the conventional method to administer aminoglycosides; however, use of once-daily dosing (ODD) has gained popularity during the last two decades. This is because ODD has a post-antibiotic effect, at least as effective as MDD, and may actually be less nephrotoxic than more frequent dosing [1]. Aminoglycoside-induced nephrotoxicity generally occurs after 5–7 days of treatment and is present as non-oligouric renal failure with a slow rise in serum creatinine