Rapid, efficient, and sensitive electrochemical nanosensors for the detection of creatinine biomolecules

مقال فى مجلة

2026

The creatinine is an important nitrogenous based organic compound recovered by the process of catabolism. Creatinine level in human blood samples are very essential because their level directly reflect to the renal, muscle, and thyroid function in human body. From the level of creatinine in human blood easily monitored and diagnosed the condition of patients. The current study initially, demonstrate the synthesis of molybdenum oxide nanorods (MoOXNRs) via solution process and characterized with a number of equipment's in detail. Thereafter, the MoOXNRs powder was utilized for sensing aptitude of creatinine (CR) with glassy carbon electrode (GCE). A number of parameters such as effect of concentrations, scan rate, cyclic test were opted and performed for the electrochemical study. A variety of analyte concentrations (CR-0.98 × 10−6 M to 500 × 10−6 M in PBS) were chosen to assess the effectiveness of the electrode based sensor (MoOXNRs/GCE). The sensor was also checked from a very low to high scan rate (5 × 10−3, to 15 × 10−2 V/s) respectively. The chronoampherometric (CrA) analysis was conducted from initial to longer intermissions (0–1000s). The cycle response (CR) and electrochemical impedance (EIS) studies were also perform and based on the data a circuit was constructed. The quantitative and qualitative detections limits values of LOD and LOQ of MoOXNRs/GCE-IPa (0.100 × 10−5: 0. 304 × 10−5) and MoOXNRs/GCE-IPc (0.619 × 10−4: 0.187 × 10−5) were also calculated. Apart from this, a possible mechanism was described in detail.