The first link between ADAMTS‑13 and apoptosis in type 1 diabetic liver injury
(https://creativecommons.org/license s/by/4.0/).
Type 1 diabetes mellitus (T1DM) is associated with oxidative stress and inflammation in the liver, which contribute to
hepatocellular damage. However, the molecular mechanisms driving this process remain poorly understood. ADAMTS-13,
a metalloprotease involved in vascular homeostasis, has been implicated in tissue remodeling and apoptosis. This study
explores the potential link between ADAMTS-13 and apoptosis in T1DM-induced liver injury. Diabetes was induced in
Wistar albino rats via streptozotocin (STZ) injection, and liver tissues were examined using immunohistochemical staining
for ADAMTS-13 and apoptotic markers, including caspase-3, caspase-8, caspase-9, and TNFR1. Expression levels were
compared between diabetic and control groups to assess correlations with apoptotic pathways. ADAMTS-13 expression
was significantly elevated in the diabetic group. Apoptotic markers also showed a significant increase (p < 0.05). Notably,
caspase-9 expression was more prominent in hepatocytes, indicating activation of the intrinsic apoptotic pathway, while
caspase-8 and TNFR1 were predominantly expressed in sinusoidal and vascular endothelial cells, suggesting involvement of
the extrinsic pathway. This study is the first to demonstrate a link between ADAMTS-13 expression and apoptosis in T1DMrelated
liver injury. These findings suggest that ADAMTS-13 may play a role in modulating apoptotic responses, although its
exact function remains to be clarified. Further mechanistic studies are warranted to determine whether ADAMTS-13 directly
influences apoptosis or represents an adaptive response to hepatic stress. Additionally, the results highlight the potential of
ADAMTS-13 as a biomarker for diabetes-associated liver dysfunction.
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Type 1 diabetes mellitus (T1DM) is associated with oxidative stress and inflammation in the liver, which contribute to
hepatocellular damage. However, the molecular mechanisms driving this…