Effect of Ferulic Acid on Cholesterol Synthesis, Serum Lipids and Hepatotoxicity in Atherogenic Rats
The effect of ferulic acid administration to atherogenic rats was investigated. 80 male Wistar rats were
assigned to two categories. The first consisted of four groups which receive normal diet and divided into
control rats, rats treated with ferulic acid (30 mg/kg body weight), simvastatin (10 mg/kg body weight)
and a combined dose of both ferulic acid and simvastatin. The second four groups received atherogenic
diet and divided into control, treated with ferulic acid, simvastatin and both ferulic acid and simvastatin
using the previous doses. Doses were administered orally on daily basis and continued for 7 successive
weeks. Serum concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol, triglycerides and glucose were determined. A significant decrease in serum levels
of total cholesterol and low-density lipoprotein cholesterol was observed in normal control and atherogenic rats treated with ferulic acid. No significant differences were observed in serum levels of high-density lipoprotein cholesterol and glucose after treating atherogenic rats with ferulic acid or simvastatin or the combination. 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity was increased in the atherogenic control group compared to their matched normal control group. Treatment of atherogenic rats with the combined dose almost restored the enzyme activity to the normal level. Oral administration of ferulic acid has a hypocholesterolaemic effect and significantly reduces 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity.
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