“Potential protective effect of bromelain and pineapple extract on gamma irradiated female rats: A study of oxidative stress, apoptosis, and hormonal changes
In the study, the pure bromelain and its natural source in pineapple extracts were examined for their protective effects on ovary function in Albino rats exposed to gamma radiation. Female Albino rats (n = 90, prepubertal, 90-140 g each) were equally divided into six experimental groups: G1 was provided with distilled water, G2 exposed to a single dose of gamma radiation (8.3 Gy), G3 was orally administered with 7 mg/kg body weight bromelain for a week, G4 resemble G3 followed by exposure to irradiation, G5 was orally dministered 30 mg/kg body weight Ananas comosus for a week, and G6 resembled G5 followed by exposure to irradiation. Rats were sacrificed one-hour, 24h, and 4 days post irradiation and histopathological alterations, granulosa cell viability and oxidative stress biomarkers and apoptosis were evaluated in the ovaries. The irradiated group experienced increased FSH and MDA levels with a reduction in E2 levels and enhanced CAT and SOD expression with marked increase in apoptosis. Treatment with both A. comosus extract and bromelain alleviated the adverse effects induced by the
radiation.
Objective: Intravenous corticosteroids, methylprednisolone (MPL), which is one of the drugs that induce glomerular kidney diseases, when used for a long time at high dose by doctors to treat acute…
Urate oxidase enzyme or uricase (UOX) is a uric acid metabolizing enzyme that exists in most terrestrial animals, except primates (including human). An elevation in uric acid levels in the blood…
In this study, we report the cloning, expression and characterization of the glutathione transferase Cloning, Phylogenetic analysis. isoenzyme P1-1 gene from Camelus dromedarius (CdGSTP1-1). The…