Attenuating effect of Indian mustard (Brassica juncea) seed and its nano formulation on arsenic induced-oxid. .
Objective: Arsenic (As) has been in the forefront of toxicological research due to its continual worldwide
human exposure and its adverse effects including genotoxicity. The study assessed the potential ameliorative effect of Indian mustard seeds (Brassica juncea) and their nanoparticles against arsenic toxicity. Methods: Male Wistar rats were used for the exposure study. Group I was control and group V was exposed only to the nanoparticles. Groups II, III, and IV were exposed to 10 mg/kg sodium arsenite for two weeks. Groups III and IV were treated with mustard seeds and the nanoparticles (500 mg/kg) respectively. Results: Arsenic intoxication caused a marked increase in the levels of As in the brain. Additionally, oxidative damage was exhibited with significantly enhanced levels of serum 8-OHdG and hepatic p53 and pS15. The pictographs and the analyzed parameters of the COMET assay illustrated DNA damage with significantly increased values of tail moment and length. Treatment with mustard seeds and its nanoparticles markedly reversed the adverse effects of As toxicity, which is attributed to the presence of a gamut of onstituent phytocompounds in the mustard seeds. Conclusion: Taken together the nano formulation was more efficacious and could be introduced as a potential nutraceutical to combat metal toxicity.
Objective: Intravenous corticosteroids, methylprednisolone (MPL), which is one of the drugs that induce glomerular kidney diseases, when used for a long time at high dose by doctors to treat acute…
Urate oxidase enzyme or uricase (UOX) is a uric acid metabolizing enzyme that exists in most terrestrial animals, except primates (including human). An elevation in uric acid levels in the blood…
In this study, we report the cloning, expression and characterization of the glutathione transferase Cloning, Phylogenetic analysis. isoenzyme P1-1 gene from Camelus dromedarius (CdGSTP1-1). The…