Heterocycles in Medicinal Chemistry (PHC 559)

The course deals with the principles and advanced topics in heterocyclic chemistry. Synthesis and reactivity of pharmacologically active heterocyclic compounds will be covered in detail, with emphasis on recent advances in commonly used strategies for synthesis of medicinally important heterocycles. The course will deal also with the synthesis of intermediates used for the construction of aromatic heterocycles. Rings that will be covered include azoles, pyridines, pyrimidines, quinolones and isoquinolines. Fused heterocyclic compounds such as indoles, benzimidazoles and purines will be covered as well.