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Alaa A.-M. Abdel-Aziz

Professor

Professor of Pharmaceutical Chemistry

كلية الصيدلة
Building 23, 2nd floor, Office 2A-114
publication
Journal Article
2016

Synthesis and antitumor evaluation of trimethoxyanilides based on 4(3H)-quinazolinone scaffolds

El-Azab, Menshawy A. Mohamed, Rezk R. Ayyad, Taghreed Z. Shawer, Alaa A.-M. Abdel-Aziz, Adel S. . 2016

A novel series of 2-[(3-substituted-4(3H)-quinazolin-2-yl)thio]-N-(3,4,5-trimethoxyphenyl)acetamide (1521) and 3-[(3-substituted-4(3H)-quinazolin-2-yl)thio])-N-(3,4,5-trimethoxyphenyl)propanamide (2329) were designed, prepared and estimated for their anticancer activity in a solo dose 10 μM of the test compounds in the NCI 57 cell lines panel assay. Compounds 20232627 and 28 revealed extensive-spectrum antitumor efficiency to numerous cell lines that belong to various tumor subpanels, while compounds 1516 and 19 possessed perceptive activity toward A498 and UO-31 renal cancer cell lines, and compound 17 showed selective effectiveness against NSC lung cancer NCI-H522 cell line. Additionally, compound 18 showed advanced activity against SR leukemia cell line, NSC lung cancer HOP-92 and renal cancer UO-31 cell lines.

Publication Work Type
Original Research Article
Volume Number
112
Pages
106–113
more of publication
publications

We report a panel of carboxylates and sulfonamides incorporating phthalic anhydride and phthalimide moieties in their structure and their interaction with the metalloenzyme carbonic anhydrase (CA…

by Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Rezk R. Ayyad, Mariangela Ceruso, Claudiu T. Supuran
2016
publications

A novel series of 2-[(3-substituted-4(3H)-quinazolin-2-yl)thio]-N-(3,4,5-trimethoxyphenyl)acetamide (1521) and 3-[(3-substituted-4(3H…

by Menshawy A. Mohamed, Rezk R. Ayyad, Taghreed Z. Shawer, Alaa A.-M. Abdel-Aziz, Adel S. El-Azab
2016
publications

Design, synthesis and pharmacological activities of a group of 1,3,5-trisubstituted pyrazolines were reported. The chemical structures of the synthesized compounds have been assigned on the basis…

by Maged A. Abdel-Sayed, Said M. Bayomi, Magda A. El-Sherbeny, Naglaa I. Abdel-Aziz, Kamal Eldin H. ElTahir, George S.G. Shehatou, Alaa A.-M. Abdel-Aziz
2016