Skip to main content
User Image

حمد بن مسفر القحطاني

Associate Professor

عضو هيئة تدريس

كلية الصيدلة
2 أ 144

Synthesis of a vanadyl (IV) folate complex for the treatment of diabetes: spectroscopic, structural, and biological characterization

Al-Wasidi, Ahmed M Naglah, Moamen S Refat, Mohamed A Al-Omar, Mashooq A Bhat, Hamad M AlKahtani, Asma S . 2019

Background: This study aimed to design a compound with folic acid (FAH2) and vanadyl (IV) for use in the treatment of diabetes.
Materials and methods: A novel vanadyl (IV) FAH2 complex was synthesized and characterized [(FA2-)(VO2+)]·3H2O. The speculated structure of this folate complex was determined using physicochemical techniques including microanalytical analysis, conductivity studies, spectroscopic examination, magnetic measurements, thermogravimetric analyses, and morphological X-ray powder diffraction, and scanning and transmission electron microscopies. The anti-diabetic therapeutic potential of the complexes was tested in a 30-day streptozotocin-induced diabetes rat model.
Results: The conductivity test of the complex implied electrolyte behavior. The spectroscopic assessments of the isolated dark yellow solid complex revealed that FAH2 acts as a bidentate ligand. The coordination process with two vanadyl (IV) ions occurred through the deprotonation of both carboxyl groups of FAH2 in a regular square pyramid arrangement at a 2(FA)2-: 2(VO)2+ molar ratio. XRD, SEM, and TEM analyses revealed the complex crystalline nature of the complex. Treating diabetic rats with vanadyl (IV) FAH2 complex significantly improved many biological parameters relevant to diabetes pathology with minimal toxicity.
Conclusion: The data generated in this study indicate that the synthesized vanadyl (IV) folate complex acts as a model of anti-diabetic agent.

Volume Number
13
Magazine \ Newspaper
Drug Design, Development and Therapy
Pages
1409
more of publication
publications

Foretinib (GSK1363089, FTB) is a multikinase inhibitor that inhibits multiple receptor tyrosine kinases, including vascular endothelial growth factor receptor-2 and mesenchymal–epithelial…

by Mohammed M Alanazi, Hamad M Alkahtani, Abdulrahman A Almehizia, Mohamed W Attwa, Ahmed H Bakheit, Hany W Darwish
2019
publications

Background: This study aimed to design a compound with folic acid (FAH2) and vanadyl (IV) for use in the treatment of diabetes.

by Ahmed M Naglah, Moamen S Refat, Mohamed A Al-Omar, Mashooq A Bhat, Hamad M AlKahtani, Asma S Al-Wasidi
2019
publications

In this work, we present the synthesis and biological evaluation of novel series of diamide-based benzenesulfonamides 5a–h as inhibitors of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1)…

by Mohamed A Abdelrahman, Wagdy M Eldehna, Alessio Nocentini, Silvia Bua, Sara T Al-Rashood, Ghada S Hassan, Alessandro Bonardi, Abdulrahman A Almehizia, Hamad M Alkahtani, Amal Alharbi, Paola Gratteri, Claudiu T Supuran
2019