The Utility Of Congo Red Stain And Cytokeratin Immunostain In The Detection Of Primary Cutaneous Amyloidosis. The Internet Journal of Pathology
Fathaddin, Ahmed Alhumidi,Amany . 2015
Abstract
Background: Primary cutaneous amyloidosis includes several forms of localized amyloidosis characterized by superficial amyloid deposits occurring at or near the dermal–epidermal junction. This type of amyloidosis is derived from keratin presents in basal keratinocytes.
Aims: To compare the cytokeratin immunohistochemoical stain and Congo red stain for the detection of primary cutaneous amyloidosis.
Methods: We examined 19 cases of cutaneous amyloidosis stained with hematoxylin–eosin, Congo red and the cytokeratin immunohistochemical stain.
Results: Most of the cases (16/19) examined were negative for Congo red stain, but all of the cases were positive for the cytokeratin immunohistochemical stain.
Conclusion: Congo red is not useful for the detection of cutaneous amyloidosis. The cytokeratin immunohistochemical stain is superior to Congo red and can detect very small amount of amyloid.
Abstract
Background: Primary cutaneous amyloidosis includes several forms of localized amyloidosis characterized by superficial amyloid deposits occurring at or near the dermal–epidermal…