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Saba Abdi

Associate Professor

Associate professor , department of biochemistry

كلية العلوم
Bulding 5, 3rd Floor, department of biochemistry, Office No. 281
المنشورات
مقال فى مجلة
2022

Association of Alzheimer’s Disease with Genetic Variants of Apolipopro-tein E, Clusterin, TNF-α, and IL-6 Among Elderly Saudis.

Background: In the wake of the warning by WHO that the prevalence of dementia may have a rise of 125% in the Middle East by 2050, identification of the genetic risk factors in Arab populations is urgent.
Objective: To investigate the association of Single Nucleotide Polymorphisms (SNPs) in apolipoprotein E (ApoE), clusterin (CLU), tumor necrotic factor- α (TNF-α) and interleukin-6 (IL-6) genes, with risk of Alzheimer’s disease (AD) in Saudi Arabian participants.
Methods: A total of 42 Saudi AD patients and 23 age-matched control participants were geno-typed for eight SNPs: rs429358, rs7412 (ApoE); rs11136000, rs1532278 (CLU); rs1800629, rs1799724 (TNF-α) and rs1800796, rs1800795(IL-6), by RT-PCR using the TaqMan assay. Se-rum concentrations of amyloid beta peptide 1–40(Aβ1-40), amyloid beta peptide 1–42(Aβ1-42), CLU and some other biochemical markers were measured.
Results: A significant increase (p=0.004) in the serum CLU level was detected in the AD group (340.4 ± 74.6) compared with control group (265.0 ± 80.9). For rs1532278 (CLU), genotype GA was significantly higher in AD patients (57.1%) than in the control participants (26.1%), [p=0.024, OR = 4.00, 95% CI (1.20-13.28)]. For the ApoE SNP rs7412, 40.4% of patients car-ried a TT genotype, whereas it was completely absent in the controls [p = 0.020, OR = 30.53, 95% CI (1.73 – 540.05)].For rs429358 (ApoE), patients showed a significantly increased fre-quency of the TC genotype [p = 0.006, OR = 9.33, 95% CI (1.89–46.19)] and TT [p = 0.045, OR = 19.76, 95% CI (1.07–366.0)] genotype than controls. AD patients with CC genotype for ApoE rs429358 had significantly lower levels of Aβ1-40 (p=0.04) in AD patients than controls. Carriers of genotype GG for rs1800629 (TNF-α) showed significantly higher levels of serum IL-6 (p = 0.04) in AD patients.
Conclusion: Genetic variants in ApoE and CLU may influence susceptibility to AD among Saudi Arabian participants.

نوع عمل المنشور
Masters
مزيد من المنشورات
publications

Abstract: This study aimed to determine the impact on the lipid profile, carboxypeptidase N (CPN)
and nitric oxide (NOx) associated with vitamin D (VD) status correction among Saudi adults…

بواسطة Yakout, Sobhy M., Saba Abdi, Alhanouf H. Alaskar, Malak Nawaz Khan Khattak, Abeer A. Al-Masri, and Nasser M. Al-Daghri
2023
publications

The exact involvement of obesity in the association with the serum levels of Fetuin-A among obese Saudi adults has not been fully clarified yet. Therefore, the present study is the first in Saudi…

بواسطة Ola Almarashda, Saba Abdi, Sobhy Yakout, Malak Nawaz, Nasser Al-Daghri
2023
publications

Background: In the wake of the warning by WHO that the prevalence of dementia may have a rise of 125% in the Middle East by 2050, identification of the genetic risk factors in Arab populations is…

بواسطة Abdi, Saba, Amani Ahmed Alghamdi, Nouf Nasser Abduallah AlGhunaim, Reem Muteb Almutairi, Farid Shokry Ataya, Mohammed Ghouse Ahmed Ansari, Syed Danish Hussain et al. "Association of Alzheimer’s Disease with Genetic Variants of Apolipopro-tein E, Clusterin
2022