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Thamer A. Almangour | ثامر بن عبدالعزيز المنقور

Assistant Professor

Faculty

كلية الصيدلة
Building 23 | Department of Clinical Pharmacy | 1st Floor | Office 1A4
المنشورات
مقال فى مجلة
2020

Dalbavancin versus standard of care for the treatment of osteomyelitis in adults: A retrospective matched cohort study

, Thamer A Almangour, Gregory Perry, Abdullah Alhifany. . 2020

Objective: To assess the safety and effectiveness of dalbavancin compared to standard of care (SOC) in the treatment of osteomyelitis in adults.
Method: A retrospective cohort study of patients with osteomyelitis due to S. aureus treated with dalbavancin was conducted. Patients who received at least 2 doses of dalbavancin for the treatment of osteomyelitis between January 1, 2015 to January 31, 2018 in a single center in Texas, USA were identified and matched in 1:1 ratio with controls who received SOC. The primary efficacy outcome was the clinical success at the end of treatment. Secondary efficacy outcome was the clinical success continued for at least 3 months after the completion of the antimicrobial therapy.
Results: During study period, 21 patients received dalbavancin for the treatment of osteomyelitis; however, only 11 patients were eligible for inclusion and matched to 11 others who received SOC. Primary outcome was achieved in all 11 patients who received dalbavancin and all those patients subsequently attained the secondary outcome. In SOC group, primary outcome occurred in 82% (9/11) of patients in which 8 out of 9 patients subsequently achieved the secondary outcome. No adverse reaction noted in either group.
Conclusion: Dalbavancin appears to be safe and effective for the management of osteomyelitis in adults. Further studies are needed to confirm these findings.
 

رقم المجلد
28
رقم الانشاء
2020
مجلة/صحيفة
Saudi Pharmaceutical Journal
الصفحات
460-464
مزيد من المنشورات