Differences and Associations of Metabolic and Vitamin D Status among Patients with and without Sub-clinical Hypothyroid Dysfunction

Journal Article
, Naji J Aljohani, Nasser M Al-Daghri, Omar S. Al-Attas, Majed S Alokail, Khalid M. Alkharfy, Abdulaziz Alothman, Sobhy Yakout, Abdulaziz F Alkabba, Ahmed S Al-Ghamdi, Mussa Almalki, Badurudeen M Buhary and Shaun Sabico, . 2013
Publication Work Type: 
Thyroid dysfunction; Obesity; Dyslipidemia; Saudi
Magazine \ Newspaper: 
BMC Medicine,2013(approved for pub)
Publication Abstract: 


Sub-clinical hypothyroid dysfunction, a relatively understudied disorder in the Kingdom of Saudi Arabia (KSA), has significant clinical implications if not properly monitored. Also from KSA, more than 50% of the population suffer from hypovitaminosis D (<50 nmol/l). In this cross-sectional case-control study, we described the differences and associations in the metabolic patterns of adult Saudis with and without hypothyroid dysfunction in relation to their vitamin D status, PTH, calcium and lipid profile.


A total of 94 consenting adult Saudis [52 controls (without subclinical hypothyroidism), 42 cases (previously diagnosed subjects)] were included in this cross-sectional study. Anthropometrics were obtained and fasting blood samples were taken for ascertaining lipid and thyroid profile, as well as measuring PTH, 25(OH) vitamin D and calcium.


Cases had a significantly higher body mass index than the controls (p < 0.001). Circulating triglycerides was also significantly higher in cases than the controls (p = 0.001). A significant positive association between HDL-cholesterol and PTH (R = 0.56; p = 0.001), as well as a negative and modestly significant negative association between LDL-cholesterol and PTH (R = - 20.0; p = 0.04) were observed. FT3 was inversely associated with circulating 25 (OH) vitamin D (R = -0.25; p = 0.01).


Patients with hypothyroid dysfunction possess several cardiometabolic risk factors that include obesity and dyslipidemia. The association between PTH and cholesterol levels as well as the inverse association between vitamin D status and FT3 needs to be reassessed prospectively on a larger scale to confirm these findings.