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Omar Salem Abdullah Al-Attas

Professor

Biochemistry

كلية العلوم
Office NO:2A 59
المنشورات
مقال فى مجلة
2012
تم النشر فى:

Pifithrin-μ increases mitochondrial COX biogenesis and MnSOD activity in skeletal muscle of middle-aged mice

, He J, Qi Z, Su Y, He Q, Liu J, Yu L, Al-Attas OS, Hussain T, De Rosas ET, Ji L, Ding S. . 2012

We investigated the biogenesis and mitochondrial antioxidant capacity of cytochrome c oxidase (COX) within the skeletal muscle under the treatments of p53 inhibitors (pifithrin, PFTα and PFTμ). Significantly, PFTμ increased mtDNA content and COX biogenesis. These changes coincided with increases in the activity and expression of manganese superoxide dismutase (MnSOD), the key antioxidant enzyme in mitochondria. Conversely, PFTα caused muscle loss, increased oxidative damage and decreased MnSOD activity in intermyofibrillar (IMF) mitochondria. Mechanically, PFTμ inhibited p53 translocation to mitochondria and thus increased its transcriptional activity for expression of synthesis of cytochrome c oxidase 2 (SCO2), an important assembly protein for COX. This study provides in vivo evidence that PFTμ, superior to PFTα, preserves muscle mass and increases mitochondrial antioxidant activity.

نوع عمل المنشور
PHD
رقم المجلد
12(6)
مجلة/صحيفة
Mitochondrion
الصفحات
630-9
مزيد من المنشورات
publications

Abstract

بواسطة Maysa Alzaim 1, Mohammed G A Ansari 2, Abeer A Al-Masri 3, Malak N K Khattak 2, Abir Alamro 4, Amani Alghamdi 4, Amal Alenad 4, Majed Alokail 5, Omar S Al-Attas 2, Ahmad G Al-Zahrani 4, Nasser M Al-Daghri 2
2024
publications

Gestational diabetes mellitus (GDM) has been linked with adverse pregnancy outcomes. Vitamin D receptor (VDR) gene variants have been associated with diabetes mellitus susceptibility and related…

بواسطة Maysa Alzaim 1, Mohammed G A Ansari 2, Abeer A Al-Masri 3, Malak N K Khattak 2, Abir Alamro 4, Amani Alghamdi 4, Amal Alenad 4, Majed Alokail 5, Omar S Al-Attas 2, Ahmad G Al-Zahrani 4, Nasser M Al-Daghri 2
2024
publications

Abstract
Objectives: To assess circulating fetuin A and fetuin B levels in participants with and without Gestational Diabetes Mellitus (GDM) and to find out their correlations with other…

بواسطة Sobhy M Yakout 1, Samira Hussein 1, Omar S Al-Attas 1, Syed D Hussain 1, Gamal M Saadawy 1, Nasser M Al-Daghri 1
2023