Single Blinded Randomized Controlled Clinical Trial on the Efficacy of Ozone Therapy on Breast Cancer-Related Lymphedema. Cancer and Clinical Oncology2013; 2 (2):93-106.

Journal Article
, 2. Intsar S. Waked, Samah H. Nagib & Mohammed T. A. Omar. . 2013
Publication Work Type: 
Original article
ozone, breast cancer- related lymphedema, doppler ultrasound
Magazine \ Newspaper: 
Cancer and Clinical Oncology
Issue Number: 
Volume Number: 
Publication Abstract: 

Purpose: The purpose of this study was to evaluate the efficacy of ozone therapy in breast cancer-related

Lymphedema (BCRL).

Methods: Sixty patients with BCRL were participated in this study and were randomly assigned to one of two

groups. Ozone group received ozone therapy in addition to complex physical therapy for lymphedema consisted

of pressure garment, remedial exercise, and skin care, while the control group received complex physical therapy

only. Limb volume was measured using water displacement and limb circumference. Skin and subcutaneous

thickness were measured using Doppler ultrasound. All measurements were carried out at baseline (0wk) and

after 12 weeks (12wk) of intervention.

Results: The clinical and demographic characteristics of both groups were comparable at baseline. The reduction

of limb volume tended to decline in both groups. The trend was more significantly pronounced in ozone group

than control at 12 wk (P < 0.05). There was significant reduction in skin and subcutis thickness in both groups.

The rate of thickness reduction was more observable in the ozone group than the control group.

Conclusion: Ozone therapy was found to be an effective adjunctive modality for reducing limb volume and

thickness in the women with BCRL.