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Khalid Siddiqui, PhD

Associate Professor

Associate Professor

كلية الطب
Strategic Center for Diabetes Research
المنشورات
مقال فى مجلة
2020

Association of urinary non-albumin protein with the different urinary marker for glomerular and tubular damage in patients with type 2 diabetes

, Khalid Siddiqui, Salini Scaria Joy, Shaik Sarfaraz Nawaz, Dhekra Alnaqeb, Muhammad Mujammami & Khalid Al-Rubeaan . 2020

Background/aim

In recent years, the diagnostic utility of urinary protein levels has been demonstrated for the early detection and progression of kidney disease. This study aimed to evaluate the associations of the non-albumin protein (NAP) with different urinary marker for tubular and glomerular damage in patients with type 2 diabetes (T2D).
Methods
In this observational cross-sectional study, 424 patients with T2D duration > 10 years were classified into two groups according to estimated glomerular filtration rate (eGFR). The ratios of different urinary markers (albumin, NAP, total protein, transferrin, retinol-binding protein (RBP), and neutrophil gelatinase-associated lipocalin (NGAL) to creatinine were analyzed.
Results
The levels of urinary biomarkers increased significantly with decrease in eGFR levels. In the group with moderately decreased eGFR, the albumin to-creatinine ratio (ACR), non-albumin protein-to-creatinine ratio (NAPCR), and total protein-to-creatinine ratio (PCR) were independently associated with all urinary markers after being adjusted for risk factors. The area under the receiver operating characteristics (ROC) curve for ACR and PCR had a better diagnostic value than other urinary biomarkers. Comparing ROC curve of NAPCR with other urinary biomarkers, it was significantly better than NGAL/Cr (p = 0.033).
Conclusions
The findings of the present study confirm that ACR and PCR are diagnostic biomarkers in T2D patients with decreased eGFR. NAPCR in these patients diagnostically only outperformed NGAL/Cr.

نوع عمل المنشور
Research Article
رقم المجلد
21
رقم الانشاء
255
مجلة/صحيفة
BMC Nephrology
مزيد من المنشورات
publications

Background: Type 1 diabetes is an autoimmune disorder with a high risk of celiac disease (CD). 

بواسطة Siddiqui, K., Nawaz, S. S., Al Sumri, N.H., Alnaqeb, D., AlQurashi ,A., & Mujammami, M.
2020
publications

Background/aim

بواسطة Khalid Siddiqui, Salini Scaria Joy, Shaik Sarfaraz Nawaz, Dhekra Alnaqeb, Muhammad Mujammami & Khalid Al-Rubeaan
2020