In-Vivo Biocompatibility and Functional Efficacy of Customized Electron Beam-Melted Titanium Mandibular Reconstruction Plates

Journal Article
Publication Work Type: 
Research Article
Volume Number: 
8
Publication Abstract: 

Background and objectives: Reconstruction of segmental maxillofacial defects is a challenge.
The objective of this study was to evaluate functional efficacy and biocompatibility of segmental
mandibular defect reconstruction, using two custom-fabricated electron-beam melted titanium
plate designs.
 Materials and methods: Using a goat model (N = 15), pre-operative computed tomography
scanning was done for custom fabrication of titanium plates. Under general anesthesia,
segmental defect was created in left mandibular body and was reconstructed using either
electron-beam melted plate (group-1; n = 5), electron-beam melted plate with mesh (group-2;
n = 5) or commercial titanium plate (group-3; n = 5). After 24-weeks, goats were sacrificed and
mandibular reconstruction was evaluated using computed-tomography and histology.
Results: Clinical and radiographic assessment revealed good functional stability with no differences between
pre-operative and post-operative parameters. Histologically, inflammatory response was observed
in 6 animals (group-1 = 3; group-2= 1; group-3=2). Dispersed material in soft and hard tissue, and
new bone formation were observed in all animals. There were no evidences of adverse tissue reaction
or foreign body reaction.
Conclusion: Custom-fabricated electron-beam melted reconstruction
plates possess biomechanical properties, functional stability and long-term biocompatibility similar
to commercial titanium plates. Electron-beam melted plates with mesh could be considered superior

because of its ability to provide scaffold for soft tissue and bone regeneration.