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Rukhsana Gul

Associate Professor

Ph.D.

كلية الطب
Obesity Research Center,

announcement

announcement

Dr. Gul is currently open to mentoring Master's and Ph.D. students in the field of biological…

introduction/brief CV

Professional Background
Dr Rukhsana Gul is an Associate Professor at Obesity Research Center (ORC), College of Medicine, King Saud University, KSA. Dr Gul has completed her Ph.D. from Department of Biochemistry, School of Medicine, Chonbuk National University, South Korea. Prior to joining ORC, Dr. Gul was working as a Postdoctoral fellow in Diabetes Research Center, Department of Internal Medicine, School of Medicine, University of Missouri, Columbia-MO, USA.
Research Description
Dr Gul has a long-standing interest in the signaling mechanisms activated by the peptide hormone Angiotensin II (Ang II) in normal development and cardiovascular pathology. Her research has taken a new direction recently with the emphasis on understanding the role of different microRNA’s in cardiovascular pathology. Her recent studies in Diabetes Research center, at the University of Missouri, have unraveled a novel role of Nebivolol, a 3rd generation beta adrenergic receptor blocker. During her Ph.D. and Postdoc training at the School of Medicine, Chonbuk National University, South Korea, Dr Gul elucidated a novel signaling pathway of ADP-ribosyl cyclase activation by Ang II in adult rat cardiomyocytes. She also demonstrated that inhibition of ADP-ribosyl cyclase by a small molecule inhibitor, 2,2'-dihydroxyazobenzene (DAB), attenuates Ang II-induced cardiac hypertrophy.
Research interests
Cellular mechanisms of obesity induced cardiac pathologies.
Current Projects
Role of β-adrenergic receptor blockers on amelioration of cardiovascular abnormalities in over-activated renin angiotensin aldosterone system
Differential effects of β-adrenergic receptor antagonists on lipopolysaccharide-induced cardiovascular pathologies.
Effects of Nanoparticles on cardiovascular pathologies induced by different agonists.
Positions available
Dr. Gul is now accepting the volunteer researchers with Master’s or Ph.D. degree in the field of biological sciences, who are interested in learning and actively participating in our ongoing research projects.
Dr Gul is also accepting students requiring a co-supervisor for their Master’s or Ph.D. research project. Students can also be assigned to the ongoing projects depending on their interest and abilities.
Selected Publications
• Gul R, Kim UH, Alfadda AA. Renin-angiotensin system at the interface of COVID-19 infection. Eur J Pharmacol. 2020 Oct 18:173656. doi: 10.1016/j.ejphar.2020.173656.
• Gul R, Park DR, Shawl AI, Im SY, Nam TS, Lee SH, Ko JK, Jang KY, Kim D, Kim UH. Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Cyclic ADP-Ribose (cADPR) Mediate Ca2+ Signaling in Cardiac Hypertrophy Induced by β-Adrenergic Stimulation. PLoS One. 2016 Mar 9;11(3): e0149125. DOI: 10.1371/journal.pone.0149125.
• Gul R, Mahmood A, Luck C1, and Pulakat L. Regulation of cardiac miR-208a, an inducer of obesity, by Rapamycin and Nebivolol. 2015, Obesity. Nov. 2015; (23): 2251–2259) .
• Arnold N, Koppula PR, Gul R, Pulakat L. Regulation of cardiac expression of the diabetic marker microRNA miR-29. July 2014; PLoS One, (9): e103284 .
• Erickson CE*, Gul R*, Pulakat L, and Andresen T. The β-blocker Nebivolol is a GRK/β-arrestin Biased Agonist., August 2013: PLoS One, (8): e71980 .
Gul R, Ramdas M, Mandavia CH, Sowers JR, Pulakat L. RAS-mediated adaptive mechanisms in cardiovascular tissues: Confounding factors of RAS blockade therapy and alternative approaches. Cardiorenal Med. 2012 Dec;2(4):268-280 .
• Gul R, Demarco VG, Sowers JR, Whaley-Connell A, Pulakat L. Regulation of Overnutrition-Induced Cardiac Inflammatory Mechanisms. Cardiorenal Med. 2012 Aug; 2(3):225-233 .
• Ma L*, Gul R*, Habibi J*, Yang M, Pulakat, Whaley-Connell A, Ferrario C, and Sowers JR. Nebivolol Improves Diastolic Dysfunction and Myocardial Remodeling through Reductions in Oxidative Stress in the Transgenic (mRen2) Rat. Am J Physiol Heart Circ Physiol. 2012 Jun 1; 302(11):H2341-51.
• Gul R, Shawl AI, Kim SH, Kim UH. Co-operative interaction between reactive oxygen species and Ca2+ signals contributes to angiotensin II-induced hypertrophy in adult rat cardiomyocytes. Am J Physiol Heart Circ Physiol 2012 Feb 15; 302(4):H901-9 .
• Shah A, Gul R, Yuan K, Shan G, Oh YB, Kim UH, and Kim SH. Angiotensin-(1-7) stimulates high atrial pacing-induced ANP secretion via Mas/PI3 kinase/Akt axis and Na+/H+ exchanger. Am J Physiol Heart Circ Physiol 2010; 298:H1365-74.
• Gul R, Park JH, Kim SY, Jang KY, Chae JK, Ko JK, Kim UH. Inhibition of ADP-ribosyl cyclase attenuates angiotensin II-induced cardiac hypertrophy. Cardiovasc Res. 2009; 81:582-91 .
• Gul R, Kim SY, Park KH, Kim BJ, Kim SJ, Im MJ, and Kim UH. A Novel Signaling Pathway of ADP-ribosyl Cyclase Activation by Angiotensin II in Adult Rat Cardiomyocytes. Am J Physiol Heart Circ Physiol. 2008; 295:H77-88.