Effect of mesenchymal stem cells on cytochrome-c release and inflammation in colon cancer induced by 1,2-dimethylhydrazine in Wistar albino rats
Colon cancer is one of the most common causes of deaths by cancer worldwide. Stem cells
have immunosuppressive properties that promote tumor targeting and circumvent obstacles
currently in gene therapy. Bone marrow stem cells are believed to have anticancer potential.
The transplantation of mesenchymal stem cells (MSCs), a type of bone marrow stem cells,
has been considered a potential therapy for patients with solid tumors due to their capability
to enhance the immune response; MSC transplantation has received renewed interest in
recent years. The present study aimed to evaluate the antiapoptotic effects of the MSCs on
1,2-dimethylhydrazine (DMH)-induced inflammation in the rat model of colorectal cancer.
The rats were randomly allocated into four groups: control, treated with MSCs, induced by
DMH, and induced by DMH and treated with MSCs. The MSCs were intra-rectally injected,
and DMH was subcutaneously injected at 20 mg/kg body weight once a week for 15 weeks.
The administration of MSCs into rats starting from day 0 of the DMH injection was found to
enhance the histopathological picture. The MSC treatment resulted in fewer inflammatory
cells than in the DMH group. Therefore, our findings suggest that BMCs have antitumor
effects by modulating the cellular redox status and down-regulating the pro-inflammatory
genes. Thus, BMCs may provide therapeutic value for colon cancer treatment.
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