540 CHEM

1. Introduction to Stereochemistry and course requirements
2. Stereoisomers, Conformational Isomerism, Ethane Conformations, Butane Conformations, Structural Equivalence and Non-equivalence of Groups, Structural Classification of Atoms or Groups
Configurational Stereoisomers of Cycloalkanes, Ring Conformers, Some Conformations of Cyclohexane Rings, Substituted Cyclohexane Compounds
3. Configurational Stereoisomers of Alkene, The Sequence Rule for Assignment of Alkene Configurations, Relationship of Constitutional and Stereoisomers
4. Chirality and Chiral compounds
5. Racemization, Formation of racemic mixtures, Diastereomers, Enantiomers and meso compounds. Chiral resolution, by crystallization, Chiral resolving agents, Chiral column chromatography,
6. Addition to Carbonyl Double Bonds, Models for Addition to Acyclic Substrates, The Chelation Effect, Non-chelating Polar Effects, Diastereoselectivity, Enantioselectivity
7. Elimination: E1 and E2 mechanism
8. Substitution: SN1, SN2 and SE mechanism
9. Rearrangement reactions