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Shaun Sabico

Associate Professor

Associate Professor and Deputy Director

كلية العلوم
Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, KSU
المنشورات
مقال فى مجلة
2024

The single point insulin sensitivity estimator (SPISE) is associated with bone health in Arab adults

Background: The Single Point Insulin Sensitivity Estimator (SPISE) index is a surrogate marker for insulin sensitivity. Given the emerging role of bone as an active endocrine organ, its associations with non-invasive measures of extra-skeletal functions such as insulin sensitivity warrant investigation.

Aims: This study aimed to explore the relationship between the SPISE index and Bone Mineral Density (BMD) in an adult population.

Methods: Data from a total of 1270 Arab adults (84% females, mean age 56.7 ± 8.1 years) from the Osteoporosis Registry Database of the Chair for Biomarkers of Chronic Diseases in King Saud University, Riyadh, Saudi Arabia was used in this study. T-scores and SPISE were calculated. Regression models were used to determine associations between SPISE and bone health indices.

Results: The low BMD group (N = 853; T-score <-1.0) had significantly higher SPISE values than those with normal BMD (N = 417; T-score - 1.0 and above) (4.6 ± 1.3 vs. 4.3 ± 1.2, p < 0.001). Multivariate linear regression, adjusted for covariates, confirmed a significant inverse association between SPISE and BMD for all participants (β=-0.22, p < 0.001), as well as both groups [normal BMD (β = -0.10, p = 0.02) and low BMD groups (β = -0.15, p < 0.001)]. SPISE, family history of T2DM, and history of fractures collectively account for 17% of the variances perceived in T-score for all participants (p < 0.001).

Conclusions: A significant inverse association between the SPISE index and BMD was observed in adults, suggesting a link between BMD and extra-skeletal health. Underlying mechanisms need to be investigated prospectively using BMD as secondary outcomes in lifestyle modification programs.

اسم الناشر
Springer Nature
مدينة النشر
Basel
رقم المجلد
36
رقم الانشاء
1
مجلة/صحيفة
Aging Clinical and Experimental Research
الصفحات
136
مزيد من المنشورات
publications

Background

بواسطة Wani K, Kumar B, Amer OE, Al-Daghri NM, Sabico S
2025
تم النشر فى:
Springer Nature
publications

Background: Fibroblast growth factor-21 (FGF21) and omentin-1 have been recognized as potent antidiabetic agents with potential hepatoprotective activity.

بواسطة Alenazi MM, Sabico S, Alnaami AM, Wani K, Hussain SD, Al-Daghri NM
2025
تم النشر فى:
Springer Nature
publications

This study investigates the 10-year atherosclerotic cardiovascular disease (ASCVD) risk in different metabolic obesity phenotypes in Saudi adults. A cohort of 5460 adults (aged 40-79) was…

بواسطة Wani K, Kumar B, Al-Daghri NM, Sabico S
2025
تم النشر فى:
Wiley