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Shaun Sabico

Assistant Professor

Assistant Professor and Deputy Director

كلية العلوم
Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, KSU
المنشورات
مقال فى مجلة
2023

The Metabolically Healthy Obese Phenotype: The Atypical Normal or Disorder in Progress?

The Metabolically Healthy Obese (MHO) is a unique phenotype of obesity in which individuals match the operational definition of obesity but do not display metabolic complications. Given this attribute, MHO has gained rapid interest in the field of adiposity research over the recent decades. Whether the MHO phenotype is apparently free of cardiometabolic abnormalities or simply a transient state of the metabolically unhealthy obese (MUO) remains controversial, but this ambiguous phenotype deserve clinical merit as it may serve as a missing conduit to further understand the complex nature of human obesity. Furthermore, shedding light in the still controversial MHO may help further research in in terms of customizing interventions aimed at decreasing the cardiometabolic risks associated with the MUO phenotypes and/or maintaining the “normalcy” of MHO over time. In this review, we aim to promote and update existing knowledge on the different metabolic health phenotypes of obesity as gathered from recent literature, primarily for the obese population and for primary care physicians who are first in-line in encountering these phenotypes. This may also help healthcare providers to have better awareness in identifying which obese phenotypes can actually benefit from weight loss programs. In light of available evidence, more longitudinal and translational studies are still needed to reach a universal definition of MHO.

اسم الناشر
Biolife Sas
رقم المجلد
37
رقم الانشاء
6
مجلة/صحيفة
Journal of Biological Regulators and Homeostatic Agents
الصفحات
2863-2876
مزيد من المنشورات
publications

Hyperglycemia associated with prediabetes (PD) alters NLRP3 inflammasome activity and related interleukins, yet no study has evaluated the expression of the NLRP3 inflammasome complex and related…

بواسطة Alfadul H, Sabico S, Alnaami AM, Amer OE, Hussain SD, Wani K, Clerici M, Al-Daghri NM
2023
تم النشر فى:
MDPI
publications

Objectives

بواسطة Aljuraiban GS, Algabsani S, Sabico S, Alshammari S, Aljazairy E, Al-Musharaf S
2023
تم النشر فى:
Elsevier
publications

The Metabolically Healthy Obese (MHO) is a unique phenotype of obesity in which individuals match the operational definition of obesity but do not display metabolic complications. Given this…

بواسطة Kaiser Wani , Balvir Kumar , Iram Saba , Shaun Sabico
2023
تم النشر فى:
Biolife Sas