An Efficient Synthesis of Novel Pyrazole-Based Heterocycles as Potential Antitumor Agents

مقال فى مجلة
Mabkho, Magda A. Abdallah 1 , Sobhi M. Gomha 1,* ID , Ikhlass M. Abbas 1 , Mariam S. H. Kazem 2 , Seham S. Alterary 3 and Yahia N. . 2017
نوع عمل المنشور
Research Article
وسوم
https://doi.org/10.3390/app7080785
مجلة/صحيفة
Applied Science
رقم الانشاء
785
رقم المجلد
7
الصفحات
13
تاريخ المؤتمر
ملخص المنشورات

Abstract: A new series of pyrazolylpyridines was prepared by reaction of ethyl-3-acetyl-1,5-diphenyl1H-pyrazole-4-carboxylate with the appropriate aldehyde, malononitrile, or ethyl acetoacetate and an excess of ammonium acetate under reflux in acetic acid. Similarly, two novel bipyridine derivatives were prepared by the above reaction using terephthaldehyde in lieu of benzaldehyde derivatives. In addition, a series of 1,2,4-triazolo[4,3-a]pyrimidines was synthesized by a reaction of 6-(pyrazol-3-yl)pyrimidine-2-thione with a number of hydrazonoyl chlorides in dioxane and in the presence of triethylamine. The structure of the produced compounds was established by elemental analyses and spectral methods, and the mechanisms of their formation was discussed. Furthermore, the pyrazolyl-pyridine derivatives were tested as anticancer agents and the results obtained showed that some of them revealed high activity against human hepatocellular carcinoma (HEPG2) cell lines.

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