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سهام بنت سليمان بن إبراهيم الطريري

Associate Professor

مشرفة وحدة تقنية النانو بالمدينة الجامعية للطالبات

كلية العلوم
المدينة الجامعية للطالبات-الدرعية/ مبنى5/ الدور الثالث/مكتب157
المنشورات
مقال فى مجلة
2017

An Efficient Synthesis of Novel Pyrazole-Based Heterocycles as Potential Antitumor Agents

Mabkho, Magda A. Abdallah 1 , Sobhi M. Gomha 1,* ID , Ikhlass M. Abbas 1 , Mariam S. H. Kazem 2 , Seham S. Alterary 3 and Yahia N. . 2017

https://doi.org/10.3390/app7080785

Abstract: A new series of pyrazolylpyridines was prepared by reaction of ethyl-3-acetyl-1,5-diphenyl1H-pyrazole-4-carboxylate with the appropriate aldehyde, malononitrile, or ethyl acetoacetate and an excess of ammonium acetate under reflux in acetic acid. Similarly, two novel bipyridine derivatives were prepared by the above reaction using terephthaldehyde in lieu of benzaldehyde derivatives. In addition, a series of 1,2,4-triazolo[4,3-a]pyrimidines was synthesized by a reaction of 6-(pyrazol-3-yl)pyrimidine-2-thione with a number of hydrazonoyl chlorides in dioxane and in the presence of triethylamine. The structure of the produced compounds was established by elemental analyses and spectral methods, and the mechanisms of their formation was discussed. Furthermore, the pyrazolyl-pyridine derivatives were tested as anticancer agents and the results obtained showed that some of them revealed high activity against human hepatocellular carcinoma (HEPG2) cell lines.

نوع عمل المنشور
Research Article
رقم المجلد
7
رقم الانشاء
785
مجلة/صحيفة
Applied Science
الصفحات
13
مزيد من المنشورات
publications

In the present work, an extract of Salvia officinalis leaves was used to synthesize an alumina/NiO nanocomposite by the coprecipitation method. First, the shape and surface content of the…

بواسطة Seham S. Alterary
2024
تم النشر فى:
American Chemical Society
publications

The unique properties of calcium oxide (CaO) and zinc oxide (ZnO) at the nanoscale have attracted the interest of scientists as promising electrically conductive substances for sensing purposes.…

بواسطة Seham S. Alterary, Gamal A. E. Mostafa, Maha F. El-Tohamy, Athar M. Elhadi, Haitham AlRabiah
2024
publications

This study is based on green synthesized nanomaterials that increase fluorescence intensity in the study of the anticancer drug palbociclib. The basis for the nanomaterials was the use of alumina/…

بواسطة Seham S. Alterary a, Gamal A.E. Mostafa b,* Maha F. El-Tohamy a, and Haitham AlRabiah
2024
تم النشر فى:
Wiley-VCH