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سهام بنت سليمان بن إبراهيم الطريري

Associate Professor

مشرفة وحدة تقنية النانو بالمدينة الجامعية للطالبات

كلية العلوم
المدينة الجامعية للطالبات-الدرعية/ مبنى5/ الدور الثالث/مكتب157
المنشورات
مقال فى مجلة
2017

Synthesis, Antitumor Evaluation and Molecular Docking of New Morpholine Based Heterocycles

4, Zeinab A. Muhammad 1, Mastoura M. Edrees 1,2 ID , Rasha A. M. Faty 3, Sobhi M. Gomha 3,* ID , Seham S. Alterary 4 and Yahia N. Mabkhot . 2017

Abstract: A series of new morpholinylchalcones was prepared and then used as building blocks for constructing a series of 7-morpholino-2-thioxo-2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-ones via their reaction with 6-aminothiouracil. The latter thiones reacted with the appropriate hydrazonoyl chloride to give the corresponding pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones. The assigned structures for all the newly synthesized compounds were confirmed on the basis of elemental analyses and spectral data and the mechanisms of their formation were also discussed. Most of the synthesized compounds were tested for in vitro activity against human lung cancer (A-549) and human hepatocellular carcinoma (HepG-2) cell lines compared with the employed standard antitumor drug (cisplatin) and the results revealed that compounds 8, 4e and 7b have promising activities against the A-549 cell line (IC50 values of 2.78±0.86 µg/mL, 5.37±0.95 µg/mL and 5.70±0.91 µg/mL, respectively) while compound 7b has promising activity against the HepG-2 cell lines (IC50 = 3.54±1.11 µg/mL). Moreover, computational studies using MOE 2014.09 software supported the biological activity results.

مزيد من المنشورات
publications

In the present work, an extract of Salvia officinalis leaves was used to synthesize an alumina/NiO nanocomposite by the coprecipitation method. First, the shape and surface content of the…

بواسطة Seham S. Alterary
2024
تم النشر فى:
American Chemical Society
publications

The unique properties of calcium oxide (CaO) and zinc oxide (ZnO) at the nanoscale have attracted the interest of scientists as promising electrically conductive substances for sensing purposes.…

بواسطة Seham S. Alterary, Gamal A. E. Mostafa, Maha F. El-Tohamy, Athar M. Elhadi, Haitham AlRabiah
2024
publications

This study is based on green synthesized nanomaterials that increase fluorescence intensity in the study of the anticancer drug palbociclib. The basis for the nanomaterials was the use of alumina/…

بواسطة Seham S. Alterary a, Gamal A.E. Mostafa b,* Maha F. El-Tohamy a, and Haitham AlRabiah
2024
تم النشر فى:
Wiley-VCH