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سهام بنت سليمان بن إبراهيم الطريري

Associate Professor

وكيــلة معهد الملك عبدالله لتقنية النانو بالمدينة الجامعية للطالبات

كلية العلوم
المدينة الجامعية للطالبات-الدرعية/ مبنى5/ الدور الثالث/مكتب157
المنشورات
مقال فى مجلة
2015

Synthesis, In-Vitro Antibacterial, Antifungal, and Molecular Modeling of Potent Anti-Microbial Agents with a Combined Pyrazole and Thiophene Pharmacophore

Frey., Yahia Nasser Mabkhot , Nahed Ahmed Kaal,, Seham Alterary, Salim S. Al-Showiman, Assem Barakat, Hazem A. Ghabbour, and Wolfgang . 2015

Research Article

Abstract

Ethyl 5-acetyl-4-methyl-2-(phenylamino)thiophene-3-carboxylate (2) and there derivatives 3a-c, 4, 6a-c and 9a-f were synthesized. The structure of compound 2 was deduced by 1H-NMR, 13C-NMR, FT-IR, MS, microanalysis, and single-crystal X-ray crystallography. The compound crystallized in the monoclinic system, with space group P21/c and cell coordinates a = 8.5752(16) Å, b = 21.046(4) Å, c = 8.2941(12) Å, β = 101.131(6)°, V = 1468.7(4) Å3, and Z = 4. Compounds 2, 3a-c, 4, 5a-c and 9a-f were subjected into in vitro antimicrobial activity tests. Compounds 3a and 3c were more potent than standard drug amphotericin B, showing MIC values of 23.8 ± 0.42 and 24.3 ± 0.68, respectively, against Aspergillus fumigatus while the standard drug MIC was 23.7 ± 0.1. Compound 3c was also more potent (MIC 24.8 ± 0.64) than the standard drug amphotericin B (MIC 19.7 ± 0.2) against Syncephalastrum racemosum. Compounds 4 and 9f also showed promising anti-microbial activity. Molecular modeling was performed for the most active compounds.

نوع عمل المنشور
مقال علمي
رقم المجلد
20
رقم الانشاء
5
مجلة/صحيفة
Molecules
الصفحات
8712-8729
مزيد من المنشورات
publications

Abstract: A new series of pyrazolylpyridines was prepared by reaction of ethyl-3-acetyl-1,5-diphenyl1H-pyrazole-4-carboxylate with the appropriate aldehyde, malononitrile, or…

بواسطة Magda A. Abdallah 1 , Sobhi M. Gomha 1,* ID , Ikhlass M. Abbas 1 , Mariam S. H. Kazem 2 , Seham S. Alterary 3 and Yahia N. Mabkho
2017
publications

Abstract: A series of new morpholinylchalcones was prepared and then used as building blocks for constructing a series of 7-morpholino-2-thioxo-2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-ones via…

بواسطة Zeinab A. Muhammad 1, Mastoura M. Edrees 1,2 ID , Rasha A. M. Faty 3, Sobhi M. Gomha 3,* ID , Seham S. Alterary 4 and Yahia N. Mabkhot 4
2017
publications

Abstract

بواسطة Yahia Nasser Mabkhot , Nahed Ahmed Kaal,, Seham Alterary, Salim S. Al-Showiman, Assem Barakat, Hazem A. Ghabbour, and Wolfgang Frey.
2015