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سهام بنت سليمان بن إبراهيم الطريري

Associate Professor

مشرفة وحدة تقنية النانو بالمدينة الجامعية للطالبات

كلية العلوم
المدينة الجامعية للطالبات-الدرعية/ مبنى5/ الدور الثالث/مكتب157
المنشورات
مقال فى مجلة
2015

Synthesis, In-Vitro Antibacterial, Antifungal, and Molecular Modeling of Potent Anti-Microbial Agents with a Combined Pyrazole and Thiophene Pharmacophore

Frey., Yahia Nasser Mabkhot , Nahed Ahmed Kaal,, Seham Alterary, Salim S. Al-Showiman, Assem Barakat, Hazem A. Ghabbour, and Wolfgang . 2015

Research Article

Abstract

Ethyl 5-acetyl-4-methyl-2-(phenylamino)thiophene-3-carboxylate (2) and there derivatives 3a-c, 4, 6a-c and 9a-f were synthesized. The structure of compound 2 was deduced by 1H-NMR, 13C-NMR, FT-IR, MS, microanalysis, and single-crystal X-ray crystallography. The compound crystallized in the monoclinic system, with space group P21/c and cell coordinates a = 8.5752(16) Å, b = 21.046(4) Å, c = 8.2941(12) Å, β = 101.131(6)°, V = 1468.7(4) Å3, and Z = 4. Compounds 2, 3a-c, 4, 5a-c and 9a-f were subjected into in vitro antimicrobial activity tests. Compounds 3a and 3c were more potent than standard drug amphotericin B, showing MIC values of 23.8 ± 0.42 and 24.3 ± 0.68, respectively, against Aspergillus fumigatus while the standard drug MIC was 23.7 ± 0.1. Compound 3c was also more potent (MIC 24.8 ± 0.64) than the standard drug amphotericin B (MIC 19.7 ± 0.2) against Syncephalastrum racemosum. Compounds 4 and 9f also showed promising anti-microbial activity. Molecular modeling was performed for the most active compounds.

نوع عمل المنشور
مقال علمي
رقم المجلد
20
رقم الانشاء
5
مجلة/صحيفة
Molecules
الصفحات
8712-8729
مزيد من المنشورات
publications

In the present work, an extract of Salvia officinalis leaves was used to synthesize an alumina/NiO nanocomposite by the coprecipitation method. First, the shape and surface content of the…

بواسطة Seham S. Alterary
2024
تم النشر فى:
American Chemical Society
publications

The unique properties of calcium oxide (CaO) and zinc oxide (ZnO) at the nanoscale have attracted the interest of scientists as promising electrically conductive substances for sensing purposes.…

بواسطة Seham S. Alterary, Gamal A. E. Mostafa, Maha F. El-Tohamy, Athar M. Elhadi, Haitham AlRabiah
2024
publications

This study is based on green synthesized nanomaterials that increase fluorescence intensity in the study of the anticancer drug palbociclib. The basis for the nanomaterials was the use of alumina/…

بواسطة Seham S. Alterary a, Gamal A.E. Mostafa b,* Maha F. El-Tohamy a, and Haitham AlRabiah
2024
تم النشر فى:
Wiley-VCH