Biotin-Bioconjugated Water-Soluble CdS Nanoparticles

مقال فى مجلة
, Al Terary, S.; Mangeney, C.; Brayner, R.; Antoun, T.; Fiévet, F.; Yassar, A . 2008
نوع عمل المنشور
مقال علمي
Research Article
Sensor Letters, American Scientific Publishers
رقم الانشاء
N⁰ 4
رقم المجلد
Vol. 6
pp. 511-517
تاريخ المؤتمر
ملخص المنشورات


Semiconductor quantum dots (QDs) are a new generation of inorganic probes with advantageous properties over traditional organic probes for biological applications. A major hurdle in the use of QDs for biology is the inability of the hydrophobically synthesized QDs to interface with aqueous environments. Here we describe the synthesis of water-soluble CdS QDs end-capped with N-hydroxysuccinimide ester groups. These CdS QDs are synthesized in polyol medium using terthiophene dicarboxylic acid as a stabilizer. The carboxylic end groups are transformed into N-hydroxysuccinimidyl ester and are further cross-linked with biotin and avidin. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy results indicate successful modification of CdS QD surfaces.