The United States of America (the U.S.) is the largest destination for international students globally, including learners from the Kingdom of Saudi Arabia. This literature review attempts to discover Saudi students' challenges while living and studying in U.S. post-secondary institutions. The researcher examined and reviewed the scientific research published on the issues and challenges Saudi students face in the U.S. from 2009 to the beginning of 2020. Thirty-seven pieces of literature met the study criteria, including doctoral and master's theses and articles published in scientific journals. After analysis and review of previous studies, it was found that Saudi students suffer from many challenges in different areas. The challenges identified in the literature are categorized into five groups: cultural and adaptation issues, family and economic challenges, health, psychological and social difficulties, and language barriers and their impact on academic achievement and educational challenges