Dr.Ramachandran Samivel

1. Research expertise: A technically competent professional with experience in Research & Development across Biochemistry & Human Physiology & cell and molecular biology. Well versed in planning and documentation of day-to-day research activities for process development, validation studies and procured the problems in cell & molecular techniques as appropriate to the timely completion of research objectives. Highly skilled in handling cutting edge research techniques on transgenic mice development, and experimental model development on tissue-specific gene knockout animal and cell line. 2. Area specification: Corneal dystrophy, Human Physiology (Heart & Kidney disease), Optical & Biomedical Imaging, Allergy Rhinitis, Nasal rhinosinusitis (Epithelial cell remodeling), Stem cell therapy, Radiation & Cancer Biology, Skin Cancer & Photobiology. 3.Teaching Experience/Employment history: (i). 2 years: Postdoctoral Researcher(Feb 2017 – Aug 2018) Cardiac hormone ANP and Guanaylyl cyclase/natriuretic receptors gene-targeted heart and kidney tissue-specific Knockout in vivo and in vitro model. Tulane Medical School, Tulane University, New Orleans LA, USA. (ii). 2 years: Postdoctoral Researcher (2015- 2017), Small animal in vivo imaging techniques, tracking live pathogens, noninvasively imaging xenograft, drug delivery, and fluorescent nanoparticle-based bio-distribution. TRPVB-ABCEP, TANUVAS, Tamil Nadu, India. (iii). 2 years: Full-time lecture/ Postdoctoral Researcher (2013-2015) Role of TRPV1 activate on CD4+ T cells mediated inflammatory response in allergic rhinitis and nasal polyps. BLI Korea, Dankook University Hospital, College of Medicine, Cheonan, South Korea. (iv). 3 month: Postdoctoral Researcher (Nov 2012-Jan 2013), Hypoxia-induced ROS generation stimulate adipose-derived stem cell proliferation and differentiation into various progenitor cells. CHA Stem cell Lab, CHA hospital, Seoul, South Korea. (v). 4 Years: Ph.D in Biochemistry (2008-2012)Preventive effect of sesamol on ultraviolet-B radiation-induced cellular and molecular changes in human skin dermal fibroblasts and Swiss albino mice. Annamalai University, Tamilnadu, India. (vi). 3 years: SRF (DST Fast Track project) 2008-2011, Evaluation of protective effect of sesamol on UVB-radiation induced cellular changes in cultured human skin dermal fibroblasts. Annamalai University, Tamilnadu, India. 4.List of present publications: 1.Umadevi Subramanian, Ramachandran Samivel, Hanqing Zhao, Venkateswara Gogulamudi, and Kailash N Pandey. Abstract 101: Transforming Growth Factor-Beta-Receptor Antagonist Blocks the Cardiac Fibrosis and Remodeling in Guanylyl Cyclase/Natriuretic Peptide Receptor-A Gene-Disrupted Mice. Hypertension, https://doi.org/10.1161/hyp.72.suppl_1.101Hypertension. 2018; 72: A101. 2. Prerna Kumar, Venkateshwara R. Gogulamudi, Christian Nguyen, Ramachandran Samivel, Kailash N. Pandey. Inhibition of Class I HDAC Enhances the Expression of Npr1 and Repairs Renal Pathology in Gene-targeted Haplotype Mice. Hypertension, 2017; P161 3. Ramachandran S, Thiyagarajan Dhinakar Raj G, Uma A. Non-invasive in vivo imaging of fluorescence-labeled bacterial distributions in aquatic specie. International Journal of Veterinary Science and Medicine 5 (2), 187-195, 2017. 4. Ramachandran Samivel, Eun Hee Kim, Jie Hye Kim, Ji Eun Kwon, Jin-Chul Ahn,Young-Jun Chung, Ji-Hun Mo. Role of TRPV1 activate on CD4+ T cells mediated inflammatory response in allergic rhinitis. Oncotarget, 2015. (IF. 6.2) 5. Eun Hee Kim, Jie Hye Kim, Ramachandran Samivel, Jun-Sang Bae, Young-Jun Chung, Phil-Sang Chung, Shee Eun Lee, Ji-Hun Mo. Intralymphatic treatment of flagellin-ovalbumin mixture reduced allergic inflammation in murine model of allergic rhinitis. Allergy, 2016. (IF. 5.8) 6. Ramachandran Samivel, Eun Hee Kim, Young-Jun Chung, Ji-Hun Mo. Immunomodulatory effect of tonsil-derived mesenchymal stem cells in a mouse model of allergic rhinitis. American Journal of Rhinology & Allergy, 2015 Jul;29(4):262-7. (IF. 2) 7. Ki-Il Lee, Dae Woo Kim,Eun Hee Kim, Jie Hye Kim, Ramachandran Samivel, Ji Eun Kwon, Jin-Chul Ahn,Young-Jun Chung, Ji-Hun Mo. Cigarette smoke promotes eosinophilic inflammation, airway remodeling, and nasal polyps in a murine polyp model. American Journal of Rhinology & Allergy, May–June 2014, Vol. 28, No. 3.(IF. 2) 8. G. Kanimozhi, S. Ramachandran, N. Rajendra Prasad, K. V. Pugalendi. Umbelliferone protects whole body irradiated Swiss albino mice: Study on animal survival, tissue antioxidant status and DNA damage. Biomedicine & Preentive Nutrition, 2012; (IF- 0.5) 9. S. Ramachandran, N. Rajendra Prasad. Sesamol modulates UVB induced apoptotic and inflammatory signaling in human skin dermal fibroblasts. Int J Nutr Pharmacol Neurol Dis. 2011; 1: 1-9. 10. S. Ramachandran, N. Rajendra Prasad. Sesamol, a phenolic in sesamum indicum, inhibits photocarcinogenesis by targeting UVB-induced lipid peroxidation and antioxidation depletion in Swiss albino mice. Journal of Research Biochemistry, 2011; 1: 001-008. 11. G. Kanimozhi, S. Ramachandran, N. Rajendra Prasad, K. V. Pugalendi. Umbelliferone modulates gamma-radiation induced ROS generation and subsequent oxidative damage in human blood lymphocytes. European Journal of Phormacology, 2011; 672(1-3): 20-29. (Impact factor: 2.8). 12. S. Ramachandran, N. Rajendra Prasad, S. Karthikeyan. Sesamol inhibits UVB-induced ROS generation and subsequent oxidative damage in cultured human skin dermal fibroblasts. Arch Dermatol Res (2010): 1–11 (Impact factor: 2.01). 13. N. Rajendra Prasad, K. Jeyanthimala and S. Ramachandran. Caffeic acid modulates ultraviolet radiation-B induced oxidative damage in human blood lymphocytes, Journal of Photochemistry & Photobiology 95/3 (2009) 196-203 (Impact factor: 2.2). 14. S. Ramachandran, N. Rajendra Prasad, Effect of ursolic acid, a triterpenoid antioxidant, in ultraviolet radiation induced cytotoxicity, lipid peroxidation and DNA damage in human lymphocytes. Chemico-Biological Interactions 176 (2008) 99–107 (Impact factor: 3.2). 15. S. Ramachandran, N. Rajendra Prasad, K.V. Pugalendi, Venugopal P. Menon Modulation of UVB-induced oxidative stress by ursolic acid in human blood lymphocytes, Asian Journal of Biochemistry 3 (1) (2008) 11-18. (Impact factor: 0.5). 16. N. Rajendra Prasad, S. Ramachandran, K.V. Pugalendi, V.P. Menon. Ferulic acid inhibits UVB induced oxidative stress, Nutrition Research 27 (9) (2007) 559-564 (Impact factor: 1.8). 5. Important Research Article Published: Molecular and Genetic Aspects of Guanylyl Cyclase Natriuretic Peptide Receptor-A in Regulation of Blood Pressure and Renal Function. Hypertension (2019 under review)