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ناصر بن محمد بن ناصر الداغري

Professor

أستاذ الكيمياء الحيوية/مشرف كرسي المؤشرات الحيوية للأمراض المزمنة

كلية العلوم
2أ51 مبنى كلية العلوم رقم 5
المنشورات
مقال فى مجلة
2020

Vitamin D Correction Down-Regulates Serum Amyloid P Component Levels in Vitamin D Deficient Arab Adults: A Single-Arm Trial

Al-Daghri, Osama E Amer 1, Malak N K Khattak 1, Abdullah M Alnaami 1, Naji J Aljohani 2, Nasser M . 2020

 

Abstract

Vitamin D (VD) has been observed to have anti-inflammatory properties. However, the effects of VD supplementation on the serum amyloid P component (SAP) has not been established. This study aimed to investigate the effect of VD supplementation on serum SAP levels in Arab adults. A total of 155 VD-deficient adult Saudis (56 males and 99 females) were recruited in this non-randomized, 6-month, single-arm trial. The intervention was as follows; cholecalciferol 50,000 international units (IU) every week for the first 2 months, followed by 50,000 twice a month for the next two months, and for the last two months, 1000 IU daily. Serum 25(OH)D, SAP, C-reactive protein (CRP), lipid profile, and glucose were assessed at baseline and post-intervention. At post-intervention, VD levels were significantly increased, while SAP levels significantly decreased in all study participants. Remarkably, this reduction in SAP was more significant in males than females after stratification. SAP was inversely correlated with VD overall (r = -0.17, p < 0.05), and only in males (r = -0.27, p < 0.05) after stratification according to sex after 6 months of VD supplementation. Such a relationship was not observed at baseline. VD supplementation can favorably modulate serum SAP concentrations in Arab adults, particularly in males.

Keywords: Arab; SAP; amyloidosis; vitamin D; vitamin D supplementation.

نوع عمل المنشور
PHD
رقم المجلد
12
رقم الانشاء
9
مجلة/صحيفة
Nutrients
الصفحات
2880
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