Biogenic green synthesis of MgO nanoparticles using Saussurea costus biomasses for a comprehensive detection of their antimicrobial, cytotoxicity against MCF-7 breast cancer cells and photocatalysis potentials

مقال فى مجلة

2020

Amina, Musarat . 2020

Distinct morphological MgO nanoparticles (MgONPs) were synthesized using biomasses of
Saussurea costus roots. The biomass of two varieties of Saussurea costus (Qustal hindi
and Qustal bahri) were used in the green synthesis of MgONPs. The physical and chemical
features of nanoparticles were confirmed by spectroscopic and microscopic techniques.
The surface morphology of the obtained nanoparticles was detected at different magnifications
by SEM and TEM microscopy and the size of nanoparticles were found to be 30 and
34 nm for Qustal hindi and Qustal bahri, respectively. The antimicrobial activity of the prepared
MgONPs was screened against six pathogenic strains. The synthesized nanoparticles
by Qustal bahri biomass exerted significant inhibition zones 15, 16, 18, 17, 14, and 10
mm against E. coli, P. aeruginosa, C. tropicalis and C. glabrata, S. aureus and B. subtilis as
compared to those from Qustal hindi 12, 8 and 17 mm against B. subtilis, E. coli and C. tropicalis,
respectively. MgONPs showed a potential cytotoxicity effect against MCF-7 breast
cancer cell lines. Cellular investigations of MgONPs revealed that the prepared nanoparticles
by Qustal bahri exhibited high cytotoxicity against MCF-7 cancer cell lines. IC50 values
in MCF-7 cells were found to be 67.3% and 52.1% for MgONPs of Saussurea costus biomasses,
respectively. Also, the photocatalytic activity of MgONPs of each Saussurea costus
variety was comparatively studied. They exhibited an enhanced photocatalytic degradation
of methylene blue after UV irradiation for 1 h as 92% and 59% for those prepared by Qustal
bahri and Qustal hindi, respectively. Outcome of results revealed that the biosynthesized
MgONPs showed promising biomedical potentials.

• مجلة/صحيفة: PLOS ONE
• الصفحات: 1-23