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Mohammad Shamsul Ola

Professor

Faculty

كلية العلوم
Research Group of Diabetic Retinopathy and Biochemical Toxicology and Nanobiochemistry; 2A 61, PO Box 2455, Building 5, Department of Biochemistry, College of Science, King Saud University, Riyadh
المنشورات
مقال فى مجلة
2017

Neuroprotective effects of quercetin in diabetic rat retina.

SS, Ola MS, Ahmed MM, Shams S, Al-Rejaie . 2017

Diabetic retinopathy (DR) is a severe complication of diabetes and the leading cause of blindness among working adults worldwide. DR is being widely recognized as a neurodegenerative disease of the retina, since, retinal neurons are damaged soon after diabetes onset. Diabetes-induced oxidative stress is considered as central factor that dysregulates neurotrophic factors and activates apoptosis, thereby damages neurons in the diabetic retina. Flavonoids being a powerful antioxidant have been considered to protect neurons in diabetic retina. The purpose of this study was to analyze the beneficial effects of flavonoid, quercetin to protect neurons in the diabetic rat retina. We quantitated the expression levels of BDNF, NGF, TrkB, synaptophysin, Akt, Bcl-2, cytochrome c and caspase-3 using Western blotting techniques in the diabetic retina with and without quercetin treatments and compared with non-diabetic rats. In addition, we employed ELISA techniques to determine the level of BDNF. Caspase-3 activity and the level of glutathione were analyzed by biochemical methods. Our results indicate that quercetin treatment to diabetic rats caused a significant increase in the level of neurotrophic factors and inhibited the level of cytochrome c and caspase-3 activity in the diabetic retina. Furthermore, the level of an anti-apoptotic protein Bcl-2 was augmented in quercetin treated diabetic retina. Thus, quercetin, may protect the neuronal damage in diabetic retina by ameliorating the levels of neurotrophic factors and also by inhibiting the apoptosis of neurons. Therefore, this study suggests that quercetin can be a suitable therapeutic agent to prevent neurodegeneration in diabetic retinopathy.

نوع عمل المنشور
Research article
رقم المجلد
24
رقم الانشاء
6
مجلة/صحيفة
Saudi J Biol Science
الصفحات
86-94
مزيد من المنشورات
publications

Background and Objectives: Phycocyanin, a water-soluble blue pigment extracted from cyanobacteria, is…

بواسطة Additiya Paramanya, Abeeb Oyesiji Abiodun, Mohammad Shamsul Ola, Ahmad Ali
2024
تم النشر فى:
Elsevier
publications

Ovarian cancer poses a significant challenge to women's health, necessitating innovative therapeutic approaches.

بواسطة Sabrina Lekmine, Ouided Benslama, Kenza Kadi, Antonio Ignacio Martín-García, Mohammad Shamsul Ola, Mustafa Abdullah Yilmaz, Ahmad Ali
2024
تم النشر فى:
Elsevier
publications

Objectives

بواسطة Md. Fahim Ahmad, Tariq Aziz, Nida Naseem, GG Hammad A. Shadab, Haseeb Ahsan, Hina Younus, Mohammad Shamsul Ola & Waseem A. Siddiqui
2024
تم النشر فى:
Springer