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Mohammad Shamsul Ola

Professor

Faculty

كلية العلوم
Research Group of Diabetic Retinopathy and Biochemical Toxicology and Nanobiochemistry; 2A 61, PO Box 2455, Building 5, Department of Biochemistry, College of Science, King Saud University, Riyadh
المنشورات
مقال فى مجلة
2018

Role of oxidative stress in diabetic retinopathy and the beneficial effects of flavonoids.

AS., Ola MS, Al-Dosari D, Alhomida . 2018

Diabetic Retinopathy (DR) is one of the leading causes of decreased vision and blindness in developed countries. Diabetes-induced metabolic disorder is believed to increase oxidative stress in the retina. This results in deleterious change through dysregulation of cellular physiology that damages both neuronal and vascular cells. In this review, we first highlight the evidence of potential metabolic sources and pathways which increase oxidative stress that contribute to retinal pathology in diabetes. As oxidative stress is a central factor in the pathophysiology of DR, antioxidants therapy would be beneficial towards preventing the retinal damage. A number of experimental studies by our group and others showed that dietary flavonoids cause reduction in increased oxidative stress and other beneficial effects in diabetic retina. We then discuss the beneficial effects of the six major flavonoid families, such as flavanones, flavanols, flavonols, isoflavones, flavones and anthocyanins, which have been studied to improve retinal damage. Flavanoids, being known antioxidants, may ameliorate the retinal degenerative factors including apoptosis, inflammation and neurodegeneration in diabetes. Therefore, intake of potential dietary flavonoids would limit oxidative stress and thereby prevent the retinal damage, and subsequently the development of DR.

نوع عمل المنشور
Research article
رقم المجلد
1
رقم الانشاء
1
مجلة/صحيفة
Current Pharm Design
الصفحات
1-10
مزيد من المنشورات
publications

Background and Objectives: Phycocyanin, a water-soluble blue pigment extracted from cyanobacteria, is…

بواسطة Additiya Paramanya, Abeeb Oyesiji Abiodun, Mohammad Shamsul Ola, Ahmad Ali
2024
تم النشر فى:
Elsevier
publications

Ovarian cancer poses a significant challenge to women's health, necessitating innovative therapeutic approaches.

بواسطة Sabrina Lekmine, Ouided Benslama, Kenza Kadi, Antonio Ignacio Martín-García, Mohammad Shamsul Ola, Mustafa Abdullah Yilmaz, Ahmad Ali
2024
تم النشر فى:
Elsevier
publications

Objectives

بواسطة Md. Fahim Ahmad, Tariq Aziz, Nida Naseem, GG Hammad A. Shadab, Haseeb Ahsan, Hina Younus, Mohammad Shamsul Ola & Waseem A. Siddiqui
2024
تم النشر فى:
Springer