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Moonis Ali Khan

Professor

Faculty

كلية العلوم
Building No. 5, Ground Floor, Room No. 51AA
المنشورات
مقال فى مجلة
2023

Harnessing Immunomodulation for Efficient Bone Regeneration: Bioengineered 2 black phosphorus-incorporated Self-Healing Hydrogel.

Osteoimmunology and immune microenvironments play an important role in bone tissue regeneration. Efficient and timely activation of pro-regenerative macrophages (M2) at the early stage is significant for new bone formation. In this study, an M2 phenotype-enabled multifunction hydrogel for efficient bone regeneration was developed. A layer of tannic acid (TA)-Mg 2+ via a simple one-step method. TA-Mg 2+ chelate networks were coated on black phosphorus (BP) nanosheets chelate on BP improves the stability of BP and enhances the osteogenesis and osteoimmunomodulation ability of BP. In addition, TA-Mg 2+ modification also enhances interfacial bonding between BP nanosheets and the hydrogel matrix. Introducing BP@TA-Mg into methacrylate silk fibroin (SFMA) hydrogel can significantly enhance the mechanical capacity and the biological activity. The resulting SFMA–BP@TA-Mg (SFBTM) hydrogel exhibits the potential to polarize macrophages towards M2 phenotype, enhance angiogenesis in human umbilical vein endothelial cells (HUVECs), and promote osteogenic differentiation in bone marrow-derived mesenchymal stem cells (BMSCs). In vivo results demonstrate that the SFBTM hydrogel significantly enhances bone regeneration by modulating the immune microenvironment and macro phage phenotype, thereby promoting the vascularization and bone regeneration at the site of bone defects. This study provides a new perspective for critical-sized bone defect treatment through immunomodulation bioactive materials.

اسم الناشر
Chemical Engineering Journal 470 (2023) 144117.
مزيد من المنشورات
publications

Skin cancer chemotherapeutics often lead to the development of severe cytotoxicity, compelling the development of novel delivery systems to not only enhance therapeutic efficacy but also minimize…

2023
تم النشر فى:
Applied Materials Today 35 (2023) 102001.
publications

Biogas and natural gas are potential renewable energy sources. They primarily contain CH4, H2, CO2, CO, C2H6, C3H8, H2S, N2, and moisture. To be used as fuel, raw biogas and natural gas require…

2023
تم النشر فى:
Chemical Engineering Journal 478 (2023) 147302
publications

A dimer of Pd(II), [(bpy)Pd(μ-OH)2Pd(bpy)]2+, (complex 1) (where bpy=2,2′-bipyridyl) has been synthesized at physiological pH (7.4) and characterized by electronic spectroscopy, electrospray…

تم النشر فى:
ACS Omega 8 (2023) 45653 – 45667.