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Mohammad Nur-e-Alam

Associate Professor

Associate Professor

كلية الصيدلة
2B39
السيرة الذاتية

Mohammad Nur-e-Alam

مختصر السيرة الذاتية
Scientific Background
I am a natural products chemist working on the isolation and analysis of novel bioactive compounds from complex biological matrices (plant and microbial fermentation extracts) and on their structural elucidation. Up to now I have isolated over 300 novel natural products and I have successfully elucidated their structures by using NMR and other spectroscopy methods. In addition I have a deep understanding of natural product biosynthesis, including the genetics and biochemistry of this process, experience with the use and development of assays for studying the biological activity of natural products.
My education involved time spent in two leading natural product chemistry laboratories, those of Professor Atta-ur-Raman and Professor M Iqbal Choudhary (Karachi, Pakistan) and Professor Jurgen Rohr (Kentucky, USA). This led to over 70 peer reviewed research articles published in leading journals and six patent applications. I have gained a deep understanding of all type of separations methods – a prerequisite for success in this area – and have become very skilled at developing methods for solving significant problems in compound isolation, and also for delineating the steps of biosynthesis and metabolism.
Befor joining here, in the last 10 years, I held an industrial position at Biotica and Bangor University, in the UK, where I was responsible for the isolation and structure elucidation of anti-cancer polyketide products. At Biotica I had enjoyed this opportunity immensely and learnt a great deal about the drug discovery process. I realise that my passion is to work in research field, being in control of my own research direction, and where I can share my interest, enthusiasm and experience in the training of young scientists
نص السيرة الذاتية

Some Relevant Publications
Nur-e-Alam Mohammad, Parveen I, Wilkinson B, Ahmed S, Hafizur R, Bari A, Woodman T, Threadgill M, Al-Rehaily A 2021. A neoclerodane orthoester and other new neoclerodane diterpenoids from Teucrium yemense chemistry and effect on secretion of insulin . Scientific Reports 11:8074
Mohammad Nur-e-Alam, Muhammad Yousaf, Ifat Parveen, Rahman M. Hafizur,Usman Ghani, Sarfaraz Ahmed, Abdul Hameed, Michael D. Threadgill and Adnan J. Al-Rehaily New flavonoids from the Saudi Arabian plant Retama raetam which stimulates secretion of insulin and inhibits α-glucosidase., Org. Biomol. Chem., 2019,17, 1266-1276
Mohammad Nur-e-Alam, Gopikkaa Kanthasamy, Muhammad Yousaf, Ali S. Alqahtani, Hazem A. Ghabbour, Adnan J. Al-Rehaily, Spectroscopy and crystal structures of natural stereoisomers of neoclerodane diterpenoids from Teucrium yemense of Saudi medicinal plant, Journal of Molecular Structure, 2017, 1147, 616–621
Wlodek A, Kendrew SG, Coates NJ, Hold A, Pogwizd J, Rudder S, Sheehan LS, Higginbotham SJ, Stanley-Smith AE, Warneck T, Nur-E-Alam Mohammad, Radzom M, Martin CJ, Overvoorde L, Samborskyy M, Alt S, Heine D, Carter GT, Graziani EI, Koehn FE, McDonald L, Alanine A, Rodríguez Sarmiento RM, Chao SK, Ratni H, Steward L, Norville IH, Sarkar-Tyson M, Moss SJ, Leadlay PF, Wilkinson B, Gregory MA. Diversity oriented biosynthesis via accelerated evolution of modular gene clusters. Nat Commun. 2017, 8, 1206
Mohammad Nur-e-Alam, Muhammad Yousaf, Sarfaraz Ahmed, Ebtesam S. Al-Sheddi, Ifat Parveen, David M. Fazakerley, Ahmed Bari, Hazem A. Ghabbour,Michael D. Threadgill, Kezia C. L. Whatley, Karl F. Hoffmann, and Adnan J. Al-Rehaily, Neoclerodane Diterpenoids from Reehal Fatima, Teucrium yemense, Journal of Natural Products, 2017, 80, 1900−1908.
Gregory, MA; Kaja, AL; Kendrew, SG; Coates, NJ; Warneck, T; Nur-e-Alam, M;. Lill, RE;. Sheehan, LS; Chudley, L;. Moss, SJ; Sheridan RM; Quimpere, M; Zhang, M-Q;. Martin, CJ and Wilkinson, B; Rational structure guided design of improved anti-proliferative rapalogs accessible through biosynthetic medicinal chemistry; Chemical Science; 2013, 4, 1046-1052
Kendrewa, SG; Petkovica, H; Gaissera, S;. Gregorya, MA; Coate, NJ; Nur-e-Alam, M; Warnecka, T; Suthara, D;. Fostera, TA; McDonaldb, L; Schlingmanb, G; Koehnb, FE; Skotnickib, JS; Carterb, GT; Moss, SJ; Zhanga, M-Q; Martina, CJ; Sheridana, RM; Wilkinson, B; Recombinant strains for the enhanced production of bioengineered rapalogs; Metabolic Engineering; 2013;15:167-73
Andexer, J.N; Kendrew, S.G; Nur-e-Alam, M; Lazos, O; Foster, T.A; Zimmermann, A.S; Warneck, T.D; Suthar, D; Coates, N.J; Koehn, F.E; Skotnicki, J.S; Carter, G.T; Gregory, M.A; Martin, C.J; Moss, S.J; Leadlay, P.F; Wilkinson, B; Biosyntesis of the immunisuppressants FK506, FK520, and rapamycin involved a previously underscribed family of enzymes acting on chorismate. PNAS;. 2011; 108 (12); 4776-81
Gibson, M; Nur-e-Alam, M; Lipata, F; Oliveira, M.A; Rohr, J; Characterization of kinetics and products of the Baeyer-Villiger oxygenase MtmOIV, the key enzyme of the biosynthetic pathway toward the natural product anticancer drug mithramycin from Streptomyces argillaceus, J Am Chem Soc. 2005; 127(50): 17594-5
Nur-e-Alam, M; Méndez, C; Salas, J. A and Rohr, J.; Elucidation of the Glycosylation Sequence of Mithramycin Biosynthesis: Isolation of 3ADeolivosylpremithramycin B and Its Conversion to Premithramycin B by Glycosyltransferase MtmGII , ChemBioChem, 2005; 6(4), 632-636