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Mohammad Mansour Algahtani

Associate Professor

Faculty

كلية الصيدلة
Building 23, 1st Floor, Room 1B 43/7

نبذة تعريفية / مختصر السيرة الذاتية

QUALIFICATIONS:

2015-2019               Ph.D. Degree in Molecular Medicine and Pharmacogenomics, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, USA.

2007-2012               Bachelor’s degree of Pharmaceutical Sciences, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

 

PROFESSIONAL CLASSIFICATION:

December 2022       Consultant.

December 2019       Senior Pharmacist.

January 2012           Pharmacist.

 

CAREER HISTORY:

2024- till now          Associate professor, Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

2019- 2024              Assistant professor, Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

2016-2019               Research Assistant, Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, USA.

2015-2016               Teaching Assistant, Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, USA.

2013-2019               Teaching Assistant, Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

2012-2013               Pharmacist II at National Guard Hospital “King Abdulaziz Medical City, Riyadh, Saudi Arabia.

                               

ADMINISTRATIVE POSITIONS:

2022- till now          Vice President of the Business Unit, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

2021-2022               Supervisor of the Faculty Support Division, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

2020-2021               Assistant Supervisor of the Postgraduate Studies Unit, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

 

PATENT:

  1. Appu Rathinavelu, Thiagarajan Venkatesan, Jayanta Das, and Mohammad Mansour S. Algahtani; Methods and composition for treatment of solid tumors using F16 isoindole small molecules (2022). Patent Publication Number: US20220409581.

 

 

مجالات الخبره

RESEARCH PAPERS:

  1. Khalid Alhazzani, Ali Alaseem, Mohammad Algahtani, Sivanesan Dhandayuthapani, Thiagarajan Venkatesan, and Appu, Rathinavelu; Angiogenesis in Cancer Treatment: 60 Years’ Swing Between Promising Trials and Disappointing Tribulations. Anti-Angiogenesis Drug Discovery and Development (2019). https://doi.org/10.2174/9781681083971119040005.
  2. Thanigaivelan Kanagasabai, Thiagarajan Venkatesan, Umamaheswari Natarajan, Saad Alobid, Khalid Alhazzani, Mohammad Algahtani, and Appu Rathinavelu; Regulation of cell cycle by MDM2 in prostate cancer cells through Aurora Kinase-B and p21WAF1/CIP1 mediated pathways. Cellular Signalling (2020). https://doi.org/10.1016/j.cellsig.2019.109435.
  3. Naif O Al-harbi, Faisal Imam, Mohammad Matar Alharbi, Mohammad Rashid Khan, Wajhul Qamar, Muhammad Afzal, Mohammad Algahtani, Saad Alobaid, Ali Salim Alfardan, Abdulrahman Alshammari, Thamer H Albekairi, and Khalid Saad Alharbi; Role of rivaroxaban in sunitinib-induced renal injuries via inhibition of oxidative stress-induced apoptosis and inflammation through the tissue nacrosis factor-α induced nuclear factor-κappa B signaling pathway in rats. Journal of Thrombosis and Thrombolysis (2020). https://doi.org/10.1007/s11239-020-02123-6.
  4. Abdulaziz Alaqil, Meshary Alkahtani, and Mohammad Algahtani; Prevalence and Predictors of Glycemic Control in Hospitalized Patients with DiabetesIndian Journal of Public Health Research & Development (2020). https://doi.org/10.37506/ijphrd.v11i11.11411.
  5. Ashraf M. Mahmoud, Mater H. Mahnashi, Khalid Alhazzani, Alanazi AZ, Mohammad M. Algahtani, Ali Alaseem, Bandar A. Alyami, Ali O. AlQarni, and Mohamed M. El-Wekil; Nitrogen doped graphene quantum dots based on host guest interaction for selective dual readout of dopamine. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (2021). https://doi.org/10.1016/j.saa.2021.119516.
  6. Mater H. Mahnashi, Ashraf M. Mahmoud, Khalid Alhazzani, A. Z. Alanazi, Ali Mohammed Alaseem, Mohammad M. Algahtani, and Mohamed M. El-Wekil; Ultrasensitive and selective molecularly imprinted electrochemical oxaliplatin sensor based on a novel nitrogen-doped carbon nanotubes/Ag@cu MOF as a signal enhancer and reporter nanohybrid. Microchim Acta (2021). https://doi.org/10.1007/s00604-021-04781-6.
  7. Mater H. Mahnashi, Ashraf M. Mahmoud, Khalid Alhazzani, Alanazi AZ, Mohammad M. Algahtani, Ali Mohammed Alaseem, Yahya S.A. Alqahtani, and Mohamed M. El-Wekil; Enhanced molecular imprinted electrochemical sensing of histamine based on signal reporting nanohybrid. Microchemical Journal (2021). https://doi.org/10.1016/j.microc.2021.106439.
  8. Khalid Alhazzani, Sheikh F. Ahmad, Naif O. Al-Harbi, Sabry M. Attia, Saleh A. Bakheet, Wedad Sarawi, Saleh A. Alqarni, Mohammad Algahtani, and Ahmed Nadeem; Pharmacological Inhibition of STAT3 by Stattic Ameliorates Clinical Symptoms and Reduces Autoinflammation in Myeloid, Lymphoid, and Neuronal Tissue Compartments in Relapsing–Remitting Model of Experimental Autoimmune Encephalomyelitis in SJL/J Mice. Pharmaceutics (2021). https://doi.org/10.3390/pharmaceutics13070925.
  9. Haneen A. Al-Mazroua, Ahmed Nadeem, Mushtaq A. Ansari, Sabry M. Attia, Saleh A. Bakheet, Thamer H. Albekairi, Nemat Ali, Fawaz Alasmari, Mohammad Algahtani, Abdulaziz M.S. Alsaad, and Sheikh F. Ahmad; CCR1 antagonist ameliorates experimental autoimmune encephalomyelitis by inhibition of Th9/Th22-related markers in the brain and periphery. Molecular Immunology (2022). https://doi.org/10.1016/j.molimm.2022.02.017.
  10. Mohammad Algahtani, Umamaheswari Natarajan, Khalid Alhazzani, Ali Alaseem, and Appu Rathinavelu; Evaluation of Anti-angiogenic Agent F16 for Targeting Glioblastoma Xenograft Tumors. Cancer Genetics (2022). https://doi.org/10.1016/j.cancergen.2022.04.001.
  11. Ahmed Nadeem, Sheikh F. Ahmad, Naif O. Al-Harbi, Laila Y Al-Ayadhi, Mohammed M Alanazi, Ali S Alfardan, Sabry M Attia, Mohammad Algahtani, and Saleh A Bakheet; Dysregulated Nrf2 signaling in response to di(2-ethylhexyl) phthalate in neutrophils of children with autism. International Immunopharmacology (2022). https://doi.org/10.1016/j.intimp.2022.108619.
  12. Khalid Alhazzani, Thiagarajan Venkatesan, Umamaheswari Natarajan, Mohammad Algahtani, Ali Alaseem, Saad Alobid, and Appu Rathinavelu; Evaluation of antitumor effects of VEGFR-2 inhibitor F16 in a colorectal xenograft model. Biotechnology Letters (2022). https://doi.org/10.1007/s10529-022-03243-0.
  13. Yousif S. Alakeel, Meshary M. Alkahtani, Omar M. Hijazi, and Mohammad M. Algahtani; Vasopressin associated hyponatremia in critically ill children: A cross-sectional study. Saudi Pharmaceutical Journal (2022). https://doi.org/10.1016/j.jsps.2022.06.006.
  14. Mashal M. Almutairi, Ahmed Nadeem, Mushtaq A. Ansari, Saleh A. Bakheet, Sabry M. Attia, Thamer H. Albekairi, Khaled Alhosaini, Mohammad Algahtani, Abdulaziz M.S. Alsaad, Haneen A. Al-Mazroua, and Sheikh F. Ahmad; Lead (Pb) exposure exacerbates behavioral and immune abnormalities by upregulating Th17 and NF-κB-related signaling in BTBR T+ Itpr3tf/J autistic mouse model. NeuroToxicology (2022). https://doi.org/10.1016/j.neuro.2022.06.007.
  15. Abdullah S. Alhamed, Mohammed Alqinyah, Musab A. Alsufayan, Ibrahim A. Alhaydan, Yasseen A. Alassmrry, Hajar O. Alnefaie, Mohammad M. Algahtani, Adel F. Alghaith, Hussain N. Alhamami, Abdullah M. Albogami, Khalid Alhazzani, and Alanazi AZ; Blockade of store-operated calcium entry sensitizes breast cancer cells to cisplatin therapy via modulating inflammatory response. Saudi Pharmaceutical Journal (2023). https://doi.org/10.1016/j.jsps.2022.12.009.
  16. Ali M. Alaseem, Khalid Alhazzani, Ahmed Zuwaiel Alanazi, Yasser Alqarni, Mohammad M. Algahtani, Abdullah S. Alhamed, Glowi Alasiri, Fahad T. Alotaibi, Talha Jawaid, and Jehad A. Aldali; Preclinical In Vitro Investigation of MDM2 Inhibition in Combination with Antiangiogenic Therapy for Breast Cancer Treatment. Scientia Pharmaceutica (2023). https://doi.org/10.3390/scipharm91010012.
  17. Sana Hanif, Muhammad Ali Syed, Ahmad Junaid Rashid, Tareq Nafea Alharby, Mohammad M. Algahtani, Muteb Alanazi, Jowaher Alanazi, and Rai Muhammad Sarfraz; Validation of a Novel RP-HPLC Technique for Simultaneous Estimation of Lignocaine Hydrochloride and Tibezonium Iodide: Greenness Estimation Using AGREE Penalties. Molecules (2023). https://doi.org/10.3390/molecules28083418.
  18. Mohammad M. Algahtani, Samiyah Alshehri, Sana S. Alqarni, Sheikh F. Ahmad, Naif O. Al-Harbi, Saleh A. Alqarni, Ali S. Alfardan, Khalid E. Ibrahim, Sabry M. Attia, and Ahmed Nadeem; Inhibition of ITK Signaling Causes Amelioration in Sepsis-Associated Neuroinflammation and Depression-like State in Mice. International Journal of Molecular Sciences (2023). https://doi.org/10.3390/ijms24098101.
  19. Talib Hussain, Muteb Alanazi, Jowaher Alanazi, Tareq Nafea Alharby, Aziz Unnisa, Amir Mahgoub Awadelkareem, AbdElmoneim O. Elkhalifa, Mohammad M. Algahtani, SMA Shahid, and Syed Mohd Danish Rizvi; Computational and In Vitro Assessment of a Natural Triterpenoid Compound Gedunin against Breast Cancer via Caspase 3 and Janus Kinase/STAT Modulation. Processes (2023). https://doi.org/10.3390/pr11051452.
  20. Mohammed Alqinyah, Abdullah S. Alhamed, Hajar O. Alnefaie, Mohammad M. Algahtani, Amira M. Badr, Abdullah M. Albogami, Mohamed Mohany, Yasseen A. Alassmrry, Adel F. Alghaith, Hussain N. Alhamami, Khalid Alhazzani, Ahmed Z. Alanazi, and Omar Awad Alsaidan; Targeting Store-Operated Calcium Entry Regulates the Inflammation-Induced Proliferation and Migration of Breast Cancer Cells. Biomedicines (2023). https://doi.org/10.3390/biomedicines11061637.
  21. Mohammad M. Algahtani, Sheikh F. Ahmad, Layla A. Alkharashi, Naif O. Al-Harbi, Wael A. Alanazi, Abdullah S. Alhamed, Sabry M. Attia, Saleh A. Bakheet, Khalid E. Ibrahim, and Ahmed Nadeem; Exposure to Methylmercury at Juvenile Stage Worsens Autism-like Symptoms in Adult BTBR T+tf/J Mice Due to Lack of Nuclear Factor Erythroid 2-Related Factor 2 Signaling Upregulation in Periphery and Brain. Toxics (2023). https://doi.org/10.3390/toxics11060546.
  22. Ahmed Z. Alanazi, Khalid Alhazzani, Salah Q. Alrewily, Khaldoon Aljerian, Mohammad M. Algahtani, Qamraa H. Alqahtani, Dhanush Haspula, Abdullah S. Alhamed, Mohammed Alqinyah, and Mohammad Raish; The Potential Protective Role of Naringenin against Dasatinib-Induced Hepatotoxicity. Pharmaceuticals (2023). https://doi.org/10.3390/ph16070921.
  23. Khalid Alhazzani, Salah Q Alrewily, Khaldoon Aljerian, Khaled Alhosaini, Mohammad M. Algahtani, Mohammed Fhad Almutery, Abdullah S Alhamed, Ahmed Nadeem, Moureq R. Alotaibi, and Ahmed Z. Alanazi; Hydroxychloroquine ameliorates dasatinib-induced liver injury via decrease in hepatic lymphocytes infiltration. Human and Experimental Toxicology (2023). http://dx.doi.org/10.1177/09603271231188492.
  24. Abdullah S. Alhamed, Mohammed Alqinyah, Adel F. Alghaith, Mohammad M. Algahtani, Faleh Alqahtani, Fahd A. Nasr, Ali S. Alqahtani, Omar M. Noman, Abdulrahman S. Bazaid, Reem Hussain AlMalki, Anas M. Abdel Rahman, Khalid Alhazzani, and Ahmed Z. Alanazi; Phytochemical analysis and anticancer activity of the Pithecellobium dulce seed extract in colorectal cancer cells. Open Chemistry (2023). https://doi.org/10.1515/chem-2023-0362.
  25. Tareq Nafea Alharby, Mohammad M. Algahtani, Jowaher Alanazi, and Muteb Alanazi; Advancing nanomedicine production via green thermal supercritical processing: Laboratory measurement and thermodynamic modeling. Journal of Molecular Liquids (2023). https://doi.org/10.1016/j.molliq.2023.122042.
  26. Jowaher Alanazi, Mohammad M. Algahtani, Muteb Alanazi, and Tareq Nafea Alharby; Application of different mathematical models based on artificial intelligence technique to predict the concentration distribution of solute through a polymeric membrane. Ecotoxicology and Environmental Safety (2023). https://doi.org/10.1016/j.ecoenv.2023.115183.
  27. Khalid Alhazzani, Meshal Alsahli, Ahmed Z Alanazi, Mohammad Algahtani, Ahmad A Alenezi, Ali Alhoshani, Mohammed Alqinyah, Abdullah S. Alhamed, and Khaled Alhosaini; Augmented antitumor effects of erlotinib and cabozantinib on A549 nonsmall cell lung cancer: In vitro and in vivo studies. Saudi Pharmaceutical Journal (2023). https://doi.org/10.1016/j.jsps.2023.101756.
  28. Layla A. Al-Kharashi, Naif O. Al-Harbi, Sheikh F. Ahmad, Sabry M. Attia, Mohammad M. Algahtani, Khalid E. Ibrahim, Saleh A. Bakheet, Mohammed M. Alanazi, Saleh A. Alqarni, Sary Alsanea, and Ahmed Nadeem; Auranofin Modulates Thioredoxin Reductase/Nrf2 Signaling in Peripheral Immune Cells and the CNS in a Mouse Model of Relapsing–Remitting EAE. Biomedicines (2023). https://doi.org/10.3390/biomedicines11092502.
  29. Layla A. Al-Kharashi, Saleh A. Alqarni, Sheikh F. Ahmad, Naif O. AlHarbi, Sary Alsanea, Khalid E. Ibrahim, Mohammad M. Algahtani, Khalid Alhazzani, Gamal A. Shazly, Mohammad M. Al-Harbi, and Ahmed Nadeem; BALB/c and C57BL/6 mice differ in oxidant and antioxidant responses in innate and adaptive immune cells in an asthma model induced by cockroach allergens. International Immunopharmacology (2023). https://doi.org/10.1016/j.intimp.2023.110892.
  30. Hussain N. Alhamami, Abdullah M. Albogami, Mohammad M. Algahtani, Mohammed Alqinyah, Wael A. Alanazi, Fawaz Alasmari, Khalid Alhazzani, Ahmed Z. Alanazi, Yasseen A. Alassmrry, and Abdullah S. Alhamed; The effect of inhibiting hindbrain A2 noradrenergic neurons by 6-Hydroxydopamine on lipopolysaccharide-treated male rats autistic animal model. Saudi Pharmaceutical Journal (2024). https://doi.org/10.1016/j.jsps.2024.101964.
  31. Mohammad M. Algahtani, Sheikh F. Ahmad, Naif O. Al-Harbi, Laila Y Al-Ayadhi, Khalid Alhazzani, Sabry M Attia, Ahmed Z. Alanazi, Saleh A Bakheet, and Ahmed Nadeem; Dysregulated Antioxidant Network and Increased iNOS Signaling in Platelets of Children with Autism Spectrum Disorder. Journal of Biological Regulators and Homeostatic Agents (2024). https://doi.org/10.23812/j.biol.regul.homeost.agents.20243805.340.
  32. Khalid Alhazzani, Hanan Mohammed, Mohammad M Algahtani, Khaldoon Aljerian, Ali Alhoshani, Homood M As Sobeai, Syed Rizwan Ahamad, Moureq R Alotaibi, Abdullah S Alhamed, Fawaz Alasmari, Mohammed Alqinyah, Hussain N Alhamami, and Ahmed Z Alanazi; Integrating Metabolomics, Histopathology, and Cardiac Marker Analysis to Assess Valsartan’s Efficacy in Mitigating Dasatinib-Induced Cardiac Toxicity in Sprague-Dawley Rats. Drug Design, Development and Therapy (2024). https://doi.org/10.2147/DDDT.S497212.

PUBLISHED ABSTRACT:

  1. Mohammad Algahtani, Khalid Alhazzani, Thiagarajan Venkatesan, Appu Rathinavelu, (2017) Apoptosis pathway focused gene expression profiling of a novel VEGFR2 inhibitor, Presented at American Association for Cancer Research (AACR) April 1-4, Washington D.C, USA.
  2. Mohammad Algahtani, Khalid Alhazzani, Sivanesan Dhandayuthapani, Thanigaivelan Kanagasabai, Appu Rathinavelu, (2017) F16 is a novel new candidate for brain tumors, Presented at Cancer Research and Targeted Therapy (CRT) Oct 26-28, Miami FL, USA.
  3. Mohammad Algahtani, Khalid Alhazzani, Thiagarajan Venkatesan, Ali Alaseem, Sivanesan Dhandayuthapani and Appu Rathinavelu, (2019) Direct cytotoxic effect of a novel anti-angiogenic drug F16 towards U87MG glioblastoma cell line, Presented at American Association for Cancer Research (AACR) March 29th – April 3rd, Atlanta GA, USA.
  4. Appu Rathinavelu, Mohammad Algahtani, Umamaheswari Natarajan, Jayanta Das, Thiagarajan Venkatesan, (2020) A novel anti-angiogenic agent F16 for the treatment of glioblastoma, Presented at American Association for Cancer Research (AACR) April 27th – 28th and June 22nd – 24th, Philadelphia PA, USA.
  5. Juan Anderson, Mariah Delgado, Malcolm Lovett, Maya Saunders, Geovannie Lake, Samuel Darko, Rose M. Stiffin, Ayivi Huisso, Marilyn Sherman, Latoya Appleton, Amalya Mihnea, Swarnava Das, Mohammad M. Algahtani, Ravi Vadapalli, Biswarup Basu, Arunima Biswas, Noor Neha, Madhumita Das, Marco A. Ruiz, Mayur Doke, Jayanta K. Das, (2024) Development of non-smoking lung cancers by indoor carcinogenic aerosols through epigenetic reprogramming of lung stem cells: Bioinformatics and artificial intelligence analysis, Presented at American Association for Cancer Research (AACR) April 5th – 10th, San Diego CA, USA.

 

الساعات المكتبية

Saturday الأحد الاثنين الثلاثاء الأربعاء الخميس الجمعة
من _ 11:00 AM _ 11:00 AM _ _ _
الى _ 01:00 PM _ 01:00 PM _ _ _
الموقع _ _ _ _ _ _ _