Protective role of propolis against histological alterations in renal tissue induced by gold nanoparticles
:MalealbinoWistarratswereexposedto10nmgoldnanoparticlesatadoseof2000µg/kgtogetherwithor withoutpropolis(50mg/kg)for15consecutivedays. Freshrenalbiopsiesfromofallinvestigatedratswerecutrapidly, fixed in neutral buffered formalin, subjected to histological processing, and examined for microanatomical alterations. Propolis gave full protection against glomerular congestion and renal tubule hyaline casts. It demonstrated partial amelioration against glomerular capillary dilatation, tubular cloudy swelling, necrosis, and degeneration together with interstitial blood capillaries dilatation and haemorrhage induced by nanoparticle toxicity. On the other hand, propolisshowednoprotectiveeffectagainstrenalcellspyknosis, karyolysis, apoptosisandrenalhydropicdegeneration together with collecting tubules atrophy and degeneration induced by the nanoparticles. Thus propolis can augment the antioxidant defence against the severity of some alterations in the renal tissues. This ameliorative role might be related to the antioxidants content of propolis that protect the renal tissues from free radicals and oxidative stress.
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Abstract: Tubulin is still a highly valued target in cancer chemotherapy. Agents that target tubulin
and microtubule dynamic are considered to be of high therapeutic potential. We conducted…