PHC 312 - Medicinal Chemistry II

The course deals with the medicinal chemistry and the pharmacological aspects of biological action of  neurotransmitters and other endogenous substances on the sympathetic and parasympathetic  autonomic nervous system as well as drugs affecting their activity. The chemical interactions of these endogenous molecules with their specific receptors or enzymes shall be covered as well as the molecular effects of their respective agonists and antagonists. Details of the mechanisms of action, SAR, stereochemistry and metabolism of these agents shall be presented. The course also deals with cardiovascular agents and diuretics, drugs that act on the CNS such as antipsychotic agents, sedatives, hypnotics, antidepressants and general anesthetics. Antihistaminics, oral hypoglycemic agents, narcotic and non-narcotic analgesics as well as local anesthetics will also be studied.