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Mammalian development is orchestrated by global transcriptional changes, which drive cellular differentiation, giving rise to diverse cell types. These transcriptional changes are mediated via Transcription factors and Epigenetic regulations. Epigenetics is defined as heritable, and reversible changes to gene expression without altering the DNA sequence. Epigenetic regulation occurs through chemical modifications on .DNA or histones, non-coding RNA expression, and chromatin structural changes